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  • Dube, FarukSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Inst för biomedicin och veterinär folkhälsovetenskap,Department of Biomedical Science and Veterinary Public Health,National Veterinary Institute (SVA) (författare)

Benzylpenicillin-producing Trichophyton erinacei and methicillin resistant Staphylococcus aureus carrying the mecC gene on European hedgehogs : a pilot-study

  • Artikel/kapitelEngelska2021

Förlag, utgivningsår, omfång ...

  • 2021-07-15
  • BioMed Central (BMC),2021
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-107635
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107635URI
  • https://doi.org/10.1186/s12866-021-02260-9DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-453772URI
  • https://res.slu.se/id/publ/113158URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The study was funded by The Royal Swedish Academy of Agriculture and Forestry (GFS2018-0069) and was co-financed by the National Veterinary Institute (SVA), Uppsala, Sweden.
  • BACKGROUND: A high carriage rate of methicillin-resistant Staphylococcus aureus with the mecC gene (mecC-MRSA) has been described among Wild European hedgehogs (Europeaus erineaus). Due to this frequent occurrence, it has been suggested that hedgehogs could be a natural reservoir for mecC-MRSA. However, the reason why hedgehogs carry mecC-MRSA remains unknown, but it has been hypothesized that mecC-MRSA could have evolved on the skin of hedgehogs due to the co-occurrence with antibiotic producing dermatophytes. The aim of this pilot-study was therefore to investigate if hedgehogs in Sweden carry Trichophyton spp. and to provide evidence that these dermatophytes are able to produce penicillin or similar substances. In addition, the study aimed to identify if dermatophytes co-occurred with mecC-MRSA.METHODS: Samples were collected from hedgehogs (Europeaus erineaus) that were euthanized or died of natural causes. All samples were screened for dermatophytes and mecC-MRSA using selective cultivation methods. Suspected isolates were characterized using PCR-based methods, genome sequencing and bioinformatic analyses. Identification of penicillin was performed by ultra-high-performance liquid chromatography-tandem mass spectrometry.RESULTS: In total 23 hedgehogs were investigated, and it was shown that two carried Trichophyton erinacei producing benzyl-penicillin, and that these hedgehogs also carried mecC-MRSA. The study also showed that 60% of the hedgehogs carried mecC-MRSA.CONCLUSION: The pilot-study demonstrated that Trichophyton erinacei, isolated from Swedish hedgehogs, can produce benzylpenicillin and that these benzylpenicillin-producing T. erinacei co-occurred with mecC-MRSA. The study also reconfirmed the high occurrence of mecC-MRSA among hedgehogs.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Söderlund, RobertDepartment of Microbiology, National Veterinary Institute, SVA, 75189, Uppsala, Sweden,Natl Vet Inst, Dept Microbiol, SVA, S-75189 Uppsala, Sweden (författare)
  • Lampinen Salomonsson, MatildaUppsala universitet,Institutionen för läkemedelskemi,Natl Vet Inst, Dept Chem Environm & Feed Hyg, SVA, S-75189 Uppsala, Sweden(Swepub:uu)malam254 (författare)
  • Troell, KarinUppsala universitet,Institutionen för medicinsk biokemi och mikrobiologi,Natl Vet Inst, Dept Microbiol, SVA, S-75189 Uppsala, Sweden(Swepub:uu)kartr688 (författare)
  • Börjesson, Stefan,1979-Department of Animal Health and Antimicrobial Strategies, National Veterinary Institute (SVA), 75189, Uppsala, Sweden; Department of Microbiology, Public Health Agency of Sweden, 17182, Solna, Sweden,Natl Vet Inst SVA, Dept Anim Hlth & Antimicrobial Strategies, S-75189 Uppsala, Sweden; Publ Hlth Agcy Sweden, Dept Microbiol, S-17182 Solna, Sweden(Swepub:oru)sebn (författare)
  • Sveriges lantbruksuniversitetInst för biomedicin och veterinär folkhälsovetenskap (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:BMC Microbiology: BioMed Central (BMC)211471-2180

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