SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Fröbert Ole)
 

Sökning: WFRF:(Fröbert Ole) > (2020-2024) > Differential Change...

  • Frøbert, Anne MetteDepartment of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark (författare)

Differential Changes in Circulating Steroid Hormones in Hibernating Brown Bears : Preliminary Conclusions and Caveats

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • University of Chicago Press,2022
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-107931
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-107931URI
  • https://doi.org/10.1086/721154DOI
  • https://res.slu.se/id/publ/120312URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding agency:Lundbeckfonden R126-2012-12408 R286-2018-367
  • Brown bears are obese when they enter the den, and after 6 mo of hibernation and physical inactivity, bears show none of the adverse consequences of a sedentary lifestyle in humans, such as cardiovascular disease, type 2 diabetes, and kidney failure. The metabolic mechanisms that drive hibernation physiology in bears are poorly defined, but systemic endocrine regulators are likely involved. To investigate the potential role of steroid hormones, we quantified the total levels of 12 steroid hormones, the precursor cholesterol, sex hormone-binding globulin (SHBG), and corticosterone-binding globulin (CBG) in paired serum samples from subadult free-ranging Scandinavian brown bears during the active and hibernation states. During hibernation, androstenedione and testosterone were significantly decreased in subadult female bears (n=13), whereas they increased in all males but one (n=6) and therefore did not reach a significant difference. Despite this difference, SHBG increased more than 20-fold during hibernation for all bears. Compared with SHBG concentrations in humans, bear levels were very low in the active state, but during hibernation, levels equaled high levels in humans. The increased SHBG levels likely maintain a state of relative quiescence of the reproductive hormones in hibernating bears. Interestingly, the combination of SHBG and testosterone levels results in similar free bioavailable testosterone levels of 70-80 pM in both subadult and adult sexually active male bears, suggesting a role for SHBG in controlling androgen action during hibernation in males. Dehydroepiandrosterone sulfate, dihydrotestosterone, and estradiol levels were below the detection limit in all but one animal. The metabolically active glucocorticoids were significantly higher in both sexes during hibernation, whereas the inactive metabolite cortisone was reduced and CBG was low approaching the detection limit. A potential caveat is that the glucocorticoid levels might be affected by the ketamine applied in the anesthetic mixture for hibernating bears. However, increased hibernating cortisol levels have consistently been reported in both black bears and brown bears. Thus, we suggest that high glucocorticoid activity may support the hibernation state, likely serving to promote lipolysis and gluconeogenesis while limiting tissue glucose uptake to maintain a continuous glucose supply to the brain.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Toews, Julia N. C.Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver British Columbia, Canada (författare)
  • Nielsen, Claus G.Department of Clinical Biochemistry, Aalborg University Hospital, Aalborg, Denmark (författare)
  • Brohus, MaleneDepartment of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark (författare)
  • Kindberg, JonasSwedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Institutionen för vilt, fisk och miljö,Department of Wildlife, Fish and Environmental Studies,Norwegian Institute for Nature Research (NINA)(Swepub:slu)48411 (författare)
  • Jessen, NielsResearch Laboratory for Biochemical Pathology, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark (författare)
  • Fröbert, Ole,1964-Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark; Department of Cardiology, Faculty of Health, Örebro University, Örebro, Sweden; Department of Clinical Medicine, Aarhus University Health, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Denmark(Swepub:oru)oft (författare)
  • Hammond, Geoffrey L.Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver British Columbia, Canada (författare)
  • Overgaard, Michael T.Department of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Aalborg, Denmark (författare)
  • Department of Chemistry and Bioscience, Faculty of Engineering and Science, Aalborg University, Aalborg, DenmarkDepartment of Cellular and Physiological Sciences, University of British Columbia, Vancouver British Columbia, Canada (creator_code:org_t)
  • Sveriges lantbruksuniversitet

Sammanhörande titlar

  • Ingår i:Physiological and Biochemical Zoology: University of Chicago Press95:5, s. 365-3781522-21521537-5293

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy