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Early life microbia...
Early life microbial exposures shape the Crassostrea gigas immune system for lifelong and intergenerational disease protection
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- Fallet, Manon, 1992- (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Montagnani, Caroline (author)
- Ifremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France
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- Petton, Bruno (author)
- Ifremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France
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- Dantan, Luc (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- de Lorgeril, Julien (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France; Ifremer, IRD, Univ Nouvelle‑Calédonie, Univ La Réunion, ENTROPIE, Nouméa, Nouvelle‑Calédonie, France
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- Comarmond, Sébastien (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Chaparro, Cristian (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Toulza, Eve (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Boitard, Simon (author)
- CBGP, CIRAD, INRAE, Institut Agro, IRD, Université de Montpellier, Montpellier, France
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- Escoubas, Jean-Michel (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Vergnes, Agnès (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Le Grand, Jacqueline (author)
- Ifremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France
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- Bulla, Ingo (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Gueguen, Yannick (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France; MARBEC, CNRS, Ifremer, IRD, Univ Montpellier, Sète, France
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- Vidal-Dupiol, Jérémie (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Grunau, Christoph (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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- Mitta, Guillaume (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France; Ifremer, UMR 241 Écosystèmes Insulaires Océaniens, Labex Corail, Centre Ifremer du Pacifique, Tahiti, French Polynesia
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- Cosseau, Céline (author)
- IHPE, CNRS, Ifremer, Univ. Montpellier, Univ. Perpignan via Domitia, Perpignan, France
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IHPE, CNRS, Ifremer, Univ Montpellier, Univ. Perpignan via Domitia, Perpignan, France Ifremer, UBO CNRS IRD, LEMAR UMR 6539, Argenton, France (creator_code:org_t)
- 2022-06-04
- 2022
- English.
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In: Microbiome. - : BioMed Central (BMC). - 2049-2618. ; 10:1
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https://doi.org/10.1...
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https://oru.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Background: The interaction of organisms with their surrounding microbial communities influences many biological processes, a notable example of which is the shaping of the immune system in early life. In the Pacific oyster, Crassostrea gigas, the role of the environmental microbial community on immune system maturation — and, importantly, protection from infectious disease — is still an open question.Results: Here, we demonstrate that early life microbial exposure durably improves oyster survival when challenged with the pathogen causing Pacific oyster mortality syndrome (POMS), both in the exposed generation and in the subsequent one. Combining microbiota, transcriptomic, genetic, and epigenetic analyses, we show that the microbial exposure induced changes in epigenetic marks and a reprogramming of immune gene expression leading to long-term and intergenerational immune protection against POMS.Conclusions: We anticipate that this protection likely extends to additional pathogens and may prove to be an important new strategy for safeguarding oyster aquaculture efforts from infectious disease
Subject headings
- NATURVETENSKAP -- Biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- Oyster
- Aquaculture
- Microbiota
- Innate immune shaping
- Epigenetic
- DNA methylation
- Biology
- Biologi
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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Microbiome
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- By the author/editor
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Fallet, Manon, 1 ...
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Montagnani, Caro ...
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Petton, Bruno
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Dantan, Luc
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de Lorgeril, Jul ...
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Comarmond, Sébas ...
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show more...
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Chaparro, Cristi ...
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Toulza, Eve
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Boitard, Simon
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Escoubas, Jean-M ...
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Vergnes, Agnès
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Le Grand, Jacque ...
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Bulla, Ingo
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Gueguen, Yannick
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Vidal-Dupiol, Jé ...
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Grunau, Christop ...
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Mitta, Guillaume
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Cosseau, Céline
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Microbiome
- By the university
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Örebro University