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Search: WFRF:(Valdimarsdóttir Unnur A.) > (2020-2024) > Psychobiological st...

  • Hardardottir, HronnCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Respiratory Medicine, Landspitali University Hospital, Reykjavik, Iceland (author)

Psychobiological stress response to a lung cancer diagnosis : a prospective study of patients in Iceland and Sweden

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Taylor & Francis,2023
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-108562
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-108562URI
  • https://doi.org/10.1080/0284186X.2023.2258445DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:153822885URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-520085URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • This work was supported by the Rannis Research Fund (grant number: 141667-051), the Swedish Cancer Foundation (grant number: 16 0720), the Doctoral Grant from the University of Iceland Research Fund/Eimskip University Fund2018, and the Landspitali University Hospital Research Fund 2015.
  • Background: A diagnostic work-up leading to a lung cancer diagnosis is a severely stressful experience that may impact tumor progression. Yet, prospective data are scarce on psychological and biological components of stress at the time of lung cancer diagnosis. The aim of this study was to assess pre-to-post diagnosis change in psychological distress and urinary excretion of catecholamines in patients with suspected lung cancer.Methods: Participants were 167 patients within the LUCASS study, recruited at referral for suspected lung cancer to University Hospitals in Iceland and Sweden. Patients completed questionnaires on perceived distress (Hospital Anxiety and Depression Scale, HADS) before and after diagnosis of lung cancer or a non-malignant origin. A subpopulation of 85 patients also provided overnight urine for catecholamine analysis before and at a median of 24 days after diagnosis but before treatment.Results: A lung cancer diagnosis was confirmed in 123 (73.7%) patients, with a mean age of 70.1 years. Patients diagnosed with lung cancer experienced a post-diagnosis increase in psychological distress (p = 0.010), while patients with non-malignant lung pathology showed a reduction in distress (p = 0.070). Both urinary epinephrine (p = 0.001) and norepinephrine (p = 0.032) levels were higher before the diagnosis among patients eventually diagnosed with lung cancer compared to those with non-malignant lung pathology. We observed indications of associations between pre-to-post diagnosis changes in perceived distress and changes in urinary catecholamine levels.Conclusion: Receiving a lung cancer diagnosis is associated with an increase in psychological distress, while elevated catecholamine levels are evident already before lung cancer diagnosis.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Aspelund, ThorCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland (author)
  • Fall, Katja,1971-Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)kafl (author)
  • Broström, ErikaUppsala universitet,Lung- allergi- och sömnforskning,Klinisk och experimentell patologi(Swepub:uu)eribr175 (author)
  • Sigurdsson, Baldur BDepartment of Clinical Chemistry, Landspitali University Hospital, Reykjavik, Iceland (author)
  • Cook, ElizabethDepartment of Clinical Chemistry, Landspitali University Hospital, Reykjavik, Iceland (author)
  • Valdimarsdottir, HeiddisDepartment of Psychology, Reykjavik University, Reykjavik, Iceland; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA (author)
  • Fang, FangKarolinska Institutet (author)
  • Sloan, Erica KMonash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia (author)
  • Lutgendorf, Susan KDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA (author)
  • Janson, ChristerUppsala universitet,Lung- allergi- och sömnforskning(Swepub:uu)chrisjn (author)
  • Valdimarsdottir, Unnur AKarolinska Institutet (author)
  • Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Respiratory Medicine, Landspitali University Hospital, Reykjavik, IcelandCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland (creator_code:org_t)

Related titles

  • In:Acta Oncologica: Taylor & Francis62:10, s. 1338-13470284-186X1651-226X

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