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Psychobiological st...
Psychobiological stress response to a lung cancer diagnosis : a prospective study of patients in Iceland and Sweden
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- Hardardottir, Hronn (författare)
- Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland; Department of Respiratory Medicine, Landspitali University Hospital, Reykjavik, Iceland
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- Aspelund, Thor (författare)
- Centre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland
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- Fall, Katja, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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- Broström, Erika (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning,Klinisk och experimentell patologi
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- Sigurdsson, Baldur B (författare)
- Department of Clinical Chemistry, Landspitali University Hospital, Reykjavik, Iceland
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- Cook, Elizabeth (författare)
- Department of Clinical Chemistry, Landspitali University Hospital, Reykjavik, Iceland
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- Valdimarsdottir, Heiddis (författare)
- Department of Psychology, Reykjavik University, Reykjavik, Iceland; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, USA
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- Fang, Fang (författare)
- Karolinska Institutet
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- Sloan, Erica K (författare)
- Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia
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- Lutgendorf, Susan K (författare)
- Department of Psychological and Brain Sciences, University of Iowa, Iowa City, Iowa, USA
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- Janson, Christer (författare)
- Uppsala universitet,Lung- allergi- och sömnforskning
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- Valdimarsdottir, Unnur A (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Taylor & Francis, 2023
- 2023
- Engelska.
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Ingår i: Acta Oncologica. - : Taylor & Francis. - 0284-186X .- 1651-226X. ; 62:10, s. 1338-1347
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: A diagnostic work-up leading to a lung cancer diagnosis is a severely stressful experience that may impact tumor progression. Yet, prospective data are scarce on psychological and biological components of stress at the time of lung cancer diagnosis. The aim of this study was to assess pre-to-post diagnosis change in psychological distress and urinary excretion of catecholamines in patients with suspected lung cancer.Methods: Participants were 167 patients within the LUCASS study, recruited at referral for suspected lung cancer to University Hospitals in Iceland and Sweden. Patients completed questionnaires on perceived distress (Hospital Anxiety and Depression Scale, HADS) before and after diagnosis of lung cancer or a non-malignant origin. A subpopulation of 85 patients also provided overnight urine for catecholamine analysis before and at a median of 24 days after diagnosis but before treatment.Results: A lung cancer diagnosis was confirmed in 123 (73.7%) patients, with a mean age of 70.1 years. Patients diagnosed with lung cancer experienced a post-diagnosis increase in psychological distress (p = 0.010), while patients with non-malignant lung pathology showed a reduction in distress (p = 0.070). Both urinary epinephrine (p = 0.001) and norepinephrine (p = 0.032) levels were higher before the diagnosis among patients eventually diagnosed with lung cancer compared to those with non-malignant lung pathology. We observed indications of associations between pre-to-post diagnosis changes in perceived distress and changes in urinary catecholamine levels.Conclusion: Receiving a lung cancer diagnosis is associated with an increase in psychological distress, while elevated catecholamine levels are evident already before lung cancer diagnosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
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Hardardottir, Hr ...
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Aspelund, Thor
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Fall, Katja, 197 ...
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Broström, Erika
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Sigurdsson, Bald ...
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Cook, Elizabeth
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Valdimarsdottir, ...
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Fang, Fang
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Sloan, Erica K
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Lutgendorf, Susa ...
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Janson, Christer
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Valdimarsdottir, ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Cancer och onkol ...
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MEDICIN OCH HÄLS ...
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och Lungmedicin och ...
- Artiklar i publikationen
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Acta Oncologica
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Örebro universitet
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Karolinska Institutet
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Uppsala universitet