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Excess Morbidity Pe...
Excess Morbidity Persists in Patients With Cushing’s Disease During Long-term Remission : A Swedish Nationwide Study
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- Papakokkinou, Eleni (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Olsson, Daniel S, 1983 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Chantzichristos, Dimitrios, 1976 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Dahlqvist, Per (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, SE-90187 Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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- Segerstedt, Elin (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, SE-90187 Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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- Olsson, Tommy (författare)
- Umeå University,Umeå universitet,Avdelningen för medicin,Umeå Univ, Dept Publ Hlth & Clin Med, SE-90187 Umeå, Sweden.,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
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- Petersson, Maria (författare)
- Karolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
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- Berinder, Katarina (författare)
- Karolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
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- Bensing, Sophie (författare)
- Karolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
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- Höybye, Charlotte (författare)
- Karolinska Institutet,Karolinska Institute,Department of Molecular Medicine and Surgery, Karolinska Institutet and The Department of Endocrinology, Metabolism and Diabetology, Karolinska University Hospital, Stockholm, Sweden
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- Engström, Britt E (författare)
- Uppsala universitet,Endokrinologi och mineralmetabolism,Department of Medical Sciences; Endocrinology, Diabetes and Metabolism, Uppsala University Hospital, Uppsala, Sweden
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- Burman, Pia (författare)
- Lund University,Lunds universitet,Translationell muskelforskning,Forskargrupper vid Lunds universitet,Translational Muscle Research,Lund University Research Groups,Skåne University Hospital,Department of Medical Sciences; Endocrinology, Diabetes and Metabolism, Uppsala University Hospital, Uppsala, Sweden
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- Bonelli, Lorenza (författare)
- Department of Endocrinology, Skåne University Hospital, University of Lund, Malmö, Sweden,Lund Univ, Skane Univ Hosp, Dept Endocrinol, SE-20502 Malmö, Sweden.
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- Follin, Cecilia (författare)
- Department of Endocrinology, Skåne University Hospital, Lund, Sweden,Skåne Univ Hosp, Dept Endocrinol, SE-22242 Lund, Sweden.
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- Petranek, David (författare)
- Department of Endocrinology, Skåne University Hospital, Lund, Sweden,Skåne Univ Hosp, Dept Endocrinol, SE-22242 Lund, Sweden.
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- Erfurth, Eva Marie (författare)
- Department of Endocrinology, Skåne University Hospital, Lund, Sweden,Skåne Univ Hosp, Dept Endocrinol, SE-22242 Lund, Sweden.
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- Wahlberg, Jeanette, 1969- (författare)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
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- Ekman, Bertil, 1958- (författare)
- Linköpings universitet,Linköping University,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken
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- Åkerman, Anna-Karin (författare)
- Karolinska Institutet,Örebro University,Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Schwarcz, Erik (författare)
- Örebro University,Department of Internal Medicine, School of Health and Medical Sciences, Örebro University, Örebro, Sweden
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- Bryngelsson, Ing-Liss (författare)
- Örebro University,Department of Occupational and Environmental Medicine, University Hospital, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Johannsson, Gudmundur, 1960 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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- Ragnarsson, Oskar, 1971 (författare)
- Gothenburg University,Göteborgs universitet,University of Gothenburg,Department of Internal Medicine and Clinical Nutrition, Institute of Medicine at Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; The Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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(creator_code:org_t)
- 2020-05-21
- 2020
- Engelska.
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Ingår i: Journal of Clinical Endocrinology and Metabolism. - Washington : Oxford University Press. - 0021-972X .- 1945-7197. ; 105:8, s. 2616-2624
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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https://lup.lub.lu.s...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Context: Whether multisystem morbidity in Cushing's disease (CD) remains elevated during long-term remission is still undetermined.Objective: To investigate comorbidities in patients with CD.Design, setting, and patients: A retrospective, nationwide study of patients with CD identified in the Swedish National Patient Register between 1987 and 2013. Individual medical records were reviewed to verify diagnosis and remission status.Main outcomes: Standardized incidence ratios (SIRs) with 95% confidence intervals (CIs) were calculated by using the Swedish general population as reference. Comorbidities were investigated during three different time periods: (i) during the 3 years before diagnosis, (ii) from diagnosis to 1 year after remission, and (iii) during long-term remission.Results: We included 502 patients with confirmed CD, of whom 419 were in remission for a median of 10 (interquartile range 4 to 21) years. SIRs (95% CI) for myocardial infarction (4.4; 1.2 to 11.4), fractures (4.9; 2.7 to 8.3), and deep vein thrombosis (13.8; 3.8 to 35.3) were increased during the 3-year period before diagnosis. From diagnosis until 1 year after remission, SIRs (95% CI were increased for thromboembolism (18.3; 7.9 to 36.0), stroke (4.9; 1.3 to 12.5), and sepsis (13.6; 3.7 to 34.8). SIRs for thromboembolism (4.9; 2.6 to 8.4), stroke (3.1; 1.8 to 4.9), and sepsis (6.0; 3.1 to 10.6) remained increased during long-term remission.Conclusion: Patients with CD have an increased incidence of stroke, thromboembolism, and sepsis even after remission, emphasizing the importance of early identification and management of risk factors for these comorbidities during long-term follow-up.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- Cushing’s disease
- cardiovascular
- comorbidity
- remission
- sepsis
- thromboembolism
- cardiovascular
- comorbidity
- Cushing’s disease
- remission
- sepsis
- thromboembolism
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Papakokkinou, El ...
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Olsson, Daniel S ...
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Chantzichristos, ...
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Dahlqvist, Per
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Segerstedt, Elin
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Olsson, Tommy
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Petersson, Maria
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Berinder, Katari ...
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Bensing, Sophie
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Höybye, Charlott ...
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Engström, Britt ...
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Burman, Pia
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Bonelli, Lorenza
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Follin, Cecilia
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Petranek, David
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Erfurth, Eva Mar ...
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Wahlberg, Jeanet ...
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Ekman, Bertil, 1 ...
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Åkerman, Anna-Ka ...
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Schwarcz, Erik
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Bryngelsson, Ing ...
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Johannsson, Gudm ...
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Ragnarsson, Oska ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Endokrinologi oc ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Örebro universitet
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Umeå universitet
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Uppsala universitet
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Lunds universitet
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Linköpings universitet
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Karolinska Institutet
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Göteborgs universitet
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