Ototoxicity associated with extended dalbavancin treatment for a shoulder prosthetic joint infection

Lange, Anna,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases (författare)

BACKGROUND: Dalbavancin is a lipoglycopeptide antibiotic approved for treatment of skin and soft tissue infections, administered as a single or two-dose treatment. The extended half-life, good penetration into bone and synovial fluid, and bactericidal activity against gram-positive bacteria, including those in biofilm, make dalbavancin an appealing choice for treatment of bone and joint infections in outpatient settings. However, we present a rare case of ototoxicity associated with off-label extended dalbavancin treatment of a prosthetic joint infection.CASE PRESENTATION: A 55-year-old man with a prosthetic joint infection of the shoulder underwent off-label extended dalbavancin treatment, receiving a cumulative dose of 2500 mg. The patient experienced a gradual onset of hearing loss following the first dose, leading to a diagnosis of bilateral sensorineural hearing loss that persisted 1 year after dalbavancin was discontinued.CONCLUSIONS: This case report highlights the importance of exercising caution when administering dalbavancin beyond approved dosing guidelines, and emphasizes the need for vigilance regarding the potential for ototoxicity.

Thunberg, Ulrica,1967-Örebro universitet,Institutionen för hälsovetenskaper,Institutionen för medicinska vetenskaper,Department of Otorhinolaryngology(Swepub:oru)uatg (författare)
Söderquist, Bo,1955-Örebro universitet,Institutionen för medicinska vetenskaper(Swepub:oru)bost (författare)
Örebro universitetInstitutionen för medicinska vetenskaper (creator_code:org_t)

Av författaren/redakt...: Lange, Anna, 197 ...; Thunberg, Ulrica ...; Söderquist, Bo, ...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Infektionsmedici ...

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