Sökning: WFRF:(Zhang Xiao Hong)
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Association of Micr...
Association of MicroRNA-652 Expression with Radiation Response of Colorectal Cancer : A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy
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- Pathak, Surajit (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Chettinad Acad Res & Educ, India
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- Meng, Wen-Jian (författare)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Sichuan Univ, Peoples R China
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- Sriramulu, Sushmitha (författare)
- Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, Chennai, India,Chettinad Acad Res & Educ, India
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- Jothimani, Ganesan (författare)
- Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, Chennai, India,Chettinad Acad Res & Educ, India
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- Jangamreddy, Jaganmohan (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Banerjee, Antara (författare)
- Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, Chennai, India,Chettinad Acad Res & Educ, India
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- Ganesan, Alagu Theivanai (författare)
- Faculty of Allied Health Sciences, Chettinad Academy of Research and Education, Chettinad Hospital and Research Institute, Kelambakkam, Tamil Nadu, Chennai, India; Department of Biotechnology, University College of Engineering, Anna University, BIT Campus, Tamil Nadu, Tiruchirappalli, India,Chettinad Acad Res & Educ, India; Anna Univ, India
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- Adell, Gunnar (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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- Zhang, Xueli (författare)
- School of Medicine, Department of Medical Sciences, Orebro University, Örebro, Sweden,Orebro Univ, Sweden
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- Sun-Zhang, Alexander (författare)
- Department of Oncology-Pathology, Karolinska Institute, Solna, Sweden,Karolinska Inst, Sweden
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- Zhang, Hong, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Orebro Univ, Sweden
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- Sun, Xiao-Feng (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Onkologiska kliniken US
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(creator_code:org_t)
- Bentham Science Publishers, 2023
- 2023
- Engelska.
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Ingår i: Current Gene Therapy. - : Bentham Science Publishers. - 1566-5232 .- 1875-5631. ; 23:5, s. 356-367
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Background: Radiotherapy is a standard adjuvant therapy in patients with progressive rectal cancer, but many patients are resistant to radiotherapy, leading to poor prognosis. Our study identified microRNA-652 (miR-652) value on radiotherapy response and outcome in rectal cancer patients.Methods: miR-652 expression was determined by qPCR in primary rectal cancer from 48 patients with and 53 patients without radiotherapy. The association of miR-652 with biological factors and the prognosis was examined. The biological function of miR-652 was identified through TCGA and GEPIA database searches. Two human colon cancer cell lines (HCT116 p53(+/+) and p53(-/-)) were used for in vitro study. The molecular interactions of miR-652 and tumor suppressor genes were studied through a computational approach.Results: In RT patients, miR-652 expression was significantly decreased in cancers when compared to non-radiotherapy cases (P = 0.002). High miR-652 expression in non-RT patients was with increased apoptosis marker (P = 0.036), ATM (P = 0.010), and DNp73 expression (P = 0.009). High miR-652 expression was related to worse disease-free survival of non-radiotherapy patients, independent of gender, age, tumor stage, and differentiation (P = 0.028; HR = 7.398, 95% CI 0.217-3.786). The biological functional analysis further identified the prognostic value and potential relationship of miR-652 with apoptosis in rectal cancer. miR-652 expression in cancers was negatively related to WRAP53 expression (P = 0.022). After miR-652 inhibition, the estimation of reactive oxygen species, caspase activity, and apoptosis in HCT116 p53(+/+ )cells was significantly increased compared with HCT116 p53(-/-) cells after radiation. The results of the molecular docking analysis show that the miR652-CTNNBL1 and miR652-TP53 were highly stable.Conclusion: Our findings suggest the potential value of miR-652 expression as a marker for the prediction of radiation response and clinical outcome in rectal cancer patients.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- miR-652
- rectal cancer
- preoperative radiotherapy
- TCGA
- prognosis
- apoptosis
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Pathak, Surajit
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Meng, Wen-Jian
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Sriramulu, Sushm ...
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Jothimani, Ganes ...
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Jangamreddy, Jag ...
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Banerjee, Antara
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Ganesan, Alagu T ...
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Adell, Gunnar
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Zhang, Xueli
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Sun-Zhang, Alexa ...
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Zhang, Hong, 195 ...
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Sun, Xiao-Feng
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och Klinisk medicin
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och Hematologi
- Artiklar i publikationen
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Current Gene The ...
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Linköpings universitet