SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Ludvigsson Jonas F.)
 

Sökning: WFRF:(Ludvigsson Jonas F.) > Histologic activity...

  • Mårild, Karl,1982Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics (författare)

Histologic activity in inflammatory bowel disease and risk of serious infections : A nationwide study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Elsevier,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-109528
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109528URI
  • https://doi.org/10.1016/j.cgh.2023.10.013DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-63034URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:237913937URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200826URI
  • https://gup.ub.gu.se/publication/335604URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:ALF-funding from Region Västra GötalandUniversity of Gothenburg, SwedenBirgitta och Göran Karlssons foundationThe Swedish Society for Medical ResearchThe Swedish Research CouncilThe Swedish Society of MedicineKarolinska InstitutetSwedish Research CouncilThe Swedish Society of MedicineRegion Stockholm (ALF project)Crohn’s and Colitis FoundationJudith Stewart Colton Center for AutoimmunityNIH NIDDK Diseases
  • In collaboration with SWIBREG Study Group.
  • BACKGROUND AND AIMS: Individuals with inflammatory bowel disease (IBD) are at increased risk of serious infections, but whether this risk varies by histological disease activity is unclear.METHODS: A national population-based study of 55,626 individuals diagnosed with IBD in 1990-2016 with longitudinal data on ileo-colorectal biopsies followed through 2016. Serious infections were defined as having an inpatient infectious disease diagnosis in the Swedish National Patient Register. We used Cox regression to estimate hazard ratios (HRs) for serious infections in the 12 months following documentation of histologic inflammation (vs. histological remission), adjusting for social and demographic factors, chronic comorbidities, prior IBD-related surgery and hospitalization. We also adjusted for IBD-related medications in sensitivity analyses.RESULTS: With histological inflammation vs. remission, there was 4.62 (95%CI=4.46-4.78) and 2.53 (95%CI=2.36-2.70) serious infections per 100 person-years of follow-up, respectively (adjusted [a]HR=1.59; 95%CI=1.48-1.72). Histological inflammation (vs. remission) were associated with an increased risk of serious infections in ulcerative colitis (UC, aHR=1.68; 95%CI=1.51-1.87) and Crohn's disease (CD, aHR=1.59; 95%CI=1.40-1.80). The aHRs of sepsis and opportunistic infections were 1.66 (95%CI=1.28-2.15) and 1.71 (95%CI=1.22-2.41), respectively. Overall, results were consistent across age groups, sex and education level and remained largely unchanged after adjustment for IBD-related medications (aHR=1.47; 95%CI=1.34-1.61).CONCLUSION: Histological inflammation of IBD was an independent risk factor of serious infections, including sepsis, suggesting that achieving histological remission may reduce infections in IBD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Söderling, JonasKarolinska Institutet,Karolinska Institutet, Solna, Sweden (författare)
  • Axelrad, JordanInflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU Grossman School of Medicine, New York, New York, USA,Inflammatory Bowel Disease Center at New York University Langone Health, Division of Gastroenterology, Department of Medicine, New York University Grossman School of Medicine, New York, New York,New York University, USA (författare)
  • Halfvarson, Jonas,1970-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)jshn (författare)
  • Forss, AndersKarolinska Institutet,Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Stockholm, Sweden (författare)
  • Olén, OlaClinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Sachs' Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden,Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden (författare)
  • Ludvigsson, Jonas F.,1969-Karolinska Institutet,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Solna, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York(Swepub:oru)jsln (författare)
  • Olsson, MalinLinköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,SWIBREG Study Group(Swepub:liu)n/a (författare)
  • Myrelid, Pär,1970-Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,SWIBREG Study Group(Swepub:liu)parmy24 (författare)
  • Hjortswang, Henrik,1966-Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Mag- tarmmedicinska kliniken,SWIBREG Study Group(Swepub:liu)henhj44 (författare)
  • Bengtsson, JonasDepartment of Surgery, Sahlgrenska University Hospital/Östra, Gothenburg, Sweden (författare)
  • Strid, HansDepartment of medicine Solna, Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Stockholm, Sweden (författare)
  • Andersson, MarieDepartment of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden (författare)
  • Jäghult, SusannaStockholm Gastro Center, Karolinska Institutet, Stockholm, Sweden (författare)
  • Eberhardson, MichaelDepartment of Gastroenterology, County Council of Östergötland and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden (författare)
  • Nordenvall, CarolineDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Colorectal Cancer Karolinska University Hospital, Stockholm, Sweden (författare)
  • Björk, JanDepartment of medicine Solna, Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Stockholm, Sweden (författare)
  • Rejler, MartinJönköping University,The Jönköping Academy for Improvement of Health and Welfare (författare)
  • Grip, OlofDepartment of Gastroenterology, Skåne University Hospital, Malmö, Sweden (författare)
  • Fagerberg, Ulrika L.Department of Women´s and Children´s Health, Karolinska Institutet, Stockholm, Sweden (författare)
  • Karling, PontusDepartment of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden (författare)
  • SWIBREG Study Group, - (bidragsgivare)
  • Göteborgs universitetInstitutionen för kliniska vetenskaper, Avdelningen för pediatrik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Clinical Gastroenterology and Hepatology: Elsevier22:4, s. 831-8461542-35651542-7714

Internetlänk

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy