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Increased proportio...
Increased proportion of circulating neutrophils with impaired phagocytosis capacity in patients with peripheral arterial disease
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- Kurt, S., 1985- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre; Irisc—inflammatory Response And Infection Susceptibility Center;
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- Pirronello, F., 1983- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Reitsema, R., 1994- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper
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- Demirel, I., 1987- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,iRiSC - Inflammatory Response and Infection Susceptibility Centre
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- Rangel, I., 1969- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Nutrition-Gut-Brain Interactions Research Centre
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- Sirsjö, A., 1959- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre (CVRC)
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- Dreifaldt, M., 1959- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Cardiothoracic and Vascular Surgery
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- Kumawat, A., 1982- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Cardiovascular Research Centre (CVRC)
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(creator_code:org_t)
- Elsevier, 2023
- 2023
- Engelska.
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Ingår i: Atherosclerosis. - : Elsevier. - 0021-9150 .- 1879-1484. ; 379:Suppl. 1, s. S22-S22
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- Background and Aims: Peripheral arterial disease (PAD) is a clinical manifestation of atherosclerosis, affecting arteries in the leg. Based on their symptoms and severity, PAD patients are characterized into three sub-groups: asymptomatic, intermittent claudication (IC) and critical limb ischemia (CLI). Despite its high prevalence, PAD remains under diagnosed and the role of immune cells in PAD pathophysiology remains poorly understood. In this study, we characterized the innate immune responses in PAD patients compared to healthy controls.Methods: Blood samples were collected from 14 patients with PAD (IC) and 30 healthy controls, to assess the phenotype of monocytes and neutrophils by using 10-colour flow cytometry. Phagocytosis assay was performed with labelled E.coli particles. Mann-Whitney U non-parametrical test was used for statistical comparison between PAD patients and healthy controls.Results: A significant higher proportion of leukocytes (p<0.05) and neutrophils (p<0.01) was observed in PAD patients compared to healthy controls, whereas monocyte subsets showed no significant differences. Interestingly, neutrophils showed a significantly impaired phagocytosis capability (p<0.05) and reduced expression of myeloperoxidase (MPO) (p<0.05) in PAD patients compared to healthy controls.Conclusions: Taken together these results, suggest that PAD patients have an increased proportion of neutrophils in circulation, with impaired phagocytosis capability, compared to healthy controls.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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- vet (ämneskategori)
- art (ämneskategori)
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Kurt, S., 1985-
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Pirronello, F., ...
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Reitsema, R., 19 ...
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Demirel, I., 198 ...
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Rangel, I., 1969 ...
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Sirsjö, A., 1959 ...
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Dreifaldt, M., 1 ...
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Kumawat, A., 198 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
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Atherosclerosis
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Örebro universitet