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  • Akhtar, ZubairBiosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Programme on Emerging Infections, Infectious Diseases Division, icddr,b, Dhaka, Bangladesh (författare)

Optimal timing of influenza vaccination among patients with acute myocardial infarction - Findings from the IAMI trial

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-109588
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109588URI
  • https://doi.org/10.1016/j.vaccine.2023.10.028DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217339URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154406416URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-200058URI
  • https://gup.ub.gu.se/publication/330119URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • This work was funded by a grant from the Swedish Heart-Lung Foundation (project number 20150284) , the Danish Heart Foundation (grant number 16-R107-A6596-22958) , ALF Grants, and Nyckelfonden, Region Örebro, Sweden and by an unrestricted grant from Sanofi Pasteur, Lyon, France, who also provided the study vaccine.
  • Funding Agencies|Swedish Heart-Lung Foundation [20150284]; Danish Heart Foundation [16-R107-A6596-22958]; ALF Grants; Nyckelfonden; Region Orebro,Sweden; Sanofi Pasteur, Lyon, France
  • Influenza vaccination reduces the risk of adverse cardiovascular events. The IAMI trial randomly assigned 2571 patients with acute myocardial infarction (AMI) to receive influenza vaccine or saline placebo during their index hospital admission. It was conducted at 30 centers in 8 countries from October 1, 2016 to March 1, 2020. In this post-hoc exploratory sub-study, we compare the trial outcomes in patients receiving early season vaccination (n = 1188) and late season vaccination (n = 1344). The primary endpoint was the composite of all-cause death, myocardial infarction (MI), or stent thrombosis at 12 months. The cumulative incidence of the primary and key secondary endpoints by randomized treatment and early or late vaccination was estimated using the Kaplan-Meier method. In the early vaccinated group, the primary composite endpoint occurred in 36 participants (6.0%) assigned to influenza vaccine and 49 (8.4%) assigned to placebo (HR 0.69; 95% CI 0.45 to 1.07), compared to 31 participants (4.7%) assigned to influenza vaccine and 42 (6.2%) assigned to placebo (HR 0.74; 95% CI 0.47 to 1.18) in the late vaccinated group (P = 0.848 for interaction on HR scale at 1 year). We observed similar estimates for the key secondary endpoints of all-cause death and CV death. There was no statistically significant difference in vaccine effectiveness against adverse cardiovascular events by timing of vaccination. The effect of vaccination on all-cause death at one year was more pronounced in the group receiving early vaccination (HR 0.50; 95% CI, 0.29 to 0.86) compared late vaccination group (HR 0.75; 35% CI, 0.40 to 1.40) but there was no statistically significant difference between these groups (Interaction P = 0.335). In conclusion, there is insufficient evidence from the trial to establish whether there is a difference in efficacy between early and late vaccination but regardless of vaccination timing we strongly recommend influenza vaccination in all patients with cardiovascular diseases.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Götberg, MatthiasDepartment of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden (författare)
  • Erlinge, DavidDepartment of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden (författare)
  • Christiansen, Evald H.Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark (författare)
  • Oldroyd, Keith G.Institute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom,Univ Glasgow, Scotland (författare)
  • Motovska, ZuzanaCardiocenter, Third Faculty of Medicine, Charles University, Prague and University Hospital Kralovske Vinohrady, Prague, Czech Republic,Charles Univ Prague, Czech Republic; Univ Hosp Kralovske Vinohrady, Czech Republic (författare)
  • Erglis, AndrejsPauls Stradins Clinical University Hospital, University of Latvia, Riga, Latvia,Univ Latvia, Latvia (författare)
  • Hlinomaz, OtaInternational Clinical Research Center, St. Anne University Hospital and Masaryk University, Brno, Czech Republic,St Anne Univ Hosp, Czech Republic; Masaryk Univ, Czech Republic (författare)
  • Jakobsen, LarsDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark,Aarhus Univ Hosp, Denmark (författare)
  • Engstrøm, ThomasRigshospitalet, University of Copenhagen, Copenhagen, Denmark,Univ Copenhagen, Denmark (författare)
  • Jensen, Lisette O.Department of Cardiology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark (författare)
  • Fallesen, Christian O.Department of Cardiology, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark (författare)
  • Jensen, Svend EDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark,Aalborg Univ Hosp, Denmark; Aalborg Univ, Denmark (författare)
  • Angerås, Oskar,1976Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine(Swepub:gu)xangos (författare)
  • Calais, Fredrik,1971-Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden,Orebro Univ, Sweden(Swepub:oru)fcs (författare)
  • Kåregren, AmraVästmanlands sjukhus Västerås, Västerås, Sweden (författare)
  • Lauermann, JorgLinköpings universitet,Institutionen för hälsa, medicin och vård,Medicinska fakulteten,Reg Jonkoping Cty, Sweden(Swepub:liu)n/a (författare)
  • Mokhtari, ArashDepartment of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden,Lund Univ, Sweden (författare)
  • Nilsson, JohanUmeå universitet,Kardiologi,Umea Univ, Sweden(Swepub:umu)joni0050 (författare)
  • Persson, JonasKarolinska Institutet,Karolinska Inst, Sweden (författare)
  • Islam, Abu K. M. M.National Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh (författare)
  • Rahman, AfzalurNational Institute of Cardiovascular Diseases, Sher-e-Bangla Nagar, Dhaka 1207, Bangladesh,Natl Inst Cardiovasc Dis, Bangladesh (författare)
  • Malik, FazilaNational Heart Foundation Hospital & Research Institute, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh (författare)
  • Choudhury, SohelNational Heart Foundation Hospital & Research Institute, Dhaka, Bangladesh,Natl Heart Fdn Hosp & Res Inst, Bangladesh (författare)
  • Collier, TimothyDepartment of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom,London Sch Hyg & Trop Med, England (författare)
  • Pocock, Stuart J.Department of Medical Statistics, London School of Hygiene and Tropical Medicine, London, United Kingdom,London Sch Hyg & Trop Med, England (författare)
  • Pernow, JohnKarolinska Institutet,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • MacIntyre, Chandini R.Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Cardiology Unit, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden,Univ New South Wales, Australia; Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Fröbert, Ole,1964-Örebro universitet, Institutionen för medicinska vetenskaper,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden; College of Public Service & Community Solutions, Arizona State University, Tempe, AZ, USA; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Arhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark,Örebro University, Faculty of Health, Department of Cardiology, Örebro, Sweden; College of Public Service & Community Solutions, Arizona State University, AZ, Tempe, United States; Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark; Department of Clinical Pharmacology, Aarhus University Hospital, Arhus, Denmark; Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark,Orebro Univ, Sweden; Arizona State Univ, AZ USA; Aarhus Univ, Denmark; Aarhus Univ Hosp, Denmark; Aarhus Univ Hosp, Denmark(Swepub:oru)oft (författare)
  • Biosecurity Program, The Kirby Institute, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia; Programme on Emerging Infections, Infectious Diseases Division, icddr,b, Dhaka, BangladeshDepartment of Cardiology, Skane University Hospital, Clinical Sciences, Lund University, Lund, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Vaccine: Elsevier41:48, s. 7159-71650264-410X1873-2518

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