Ocular Fundus Morphology and Visual Function in Adolescents Born Moderate-to-Late Preterm

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Ali, SaraDepartment of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden (author)

Ocular Fundus Morphology and Visual Function in Adolescents Born Moderate-to-Late Preterm

Article/chapterEnglish2023

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Association for Research in Vision and Ophthalmology,2023
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LIBRIS-ID:oai:DiVA.org:oru-109688
https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109688URI

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Language:English
Summary in:English

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Purpose: Previous studies have mostly focused on ophthalmological complications associated with being born extremely preterm despite that moderate-to-late preterm (MLP) account for 85% of all preterm births. The aim was to examine fundus morphology and visual function in adolescents born MLP, in comparison with controls born full-term.Methods: A prospective population-based cohort study of 247 MLP individuals (110 girls, gestational age 32-36 weeks) with no syndromes or history of retinopathy of prematurity participated in a neonatal study in 2002-2004. Later on, they have been included in ophthalmological follow-up studies at age 8 (n=50) and 12 (n=22). In the present study, 50 adolescents (26 girls; mean age 16.5 years) were examined regarding best corrected visual acuity (BCVA), refraction, and ocular morphology, measured by optical coherence tomography (Topcon, Japan). A group of 50 adolescents (30 girls, mean age 16.7 years) born full-term served as controls. Participants with refraction outside +/-6 diopters were excluded. T-test was used for statistical analysis.Results: The MLP-group (n=48) showed a thinner macular retinal nerve fibre layer (RNFL) inner mean in right eye (RE) (26.4±1.5 vs 27.1±1.7 μm; p=0.029) and in left eye (LE) (26.3±1.5 vs 27.0±1.5 μm; p=0.022) compared with controls. A thinner macular RNFL outer mean was found both in RE (40.2±4.4 vs 42.6±4.2 μm; p=0.011) and LE (40.3±4.0 vs 42.1±4.3 μm; p=0.034) (Fig.1A-B). A thicker central macular retinal thickness (MRT) (249.3±20.9 vs 239.9±16.4 μm; p=0.016) and a thinner total peripapillary (pp)RNFL (104.8±8.8 vs 109.1±8.3 μm; p=0.027) were found in RE. The BCVA in best eye was lower in the MLP-group (n=50) compared with controls (-0.09±0.08 vs -0.12±0.09 logMAR; p=0.022). At age 8, MLP births showed a thinner total macular volume and a thicker foveal minimum, central MRT, and central macular RNFL in RE. At age 12, a thicker foveal minimum and thinner outer macular RNFL were found in LE.Conclusions: MLP-birth may be associated with ophthalmological macular and ppRNFL changes as well as lower BCVA in adolescence. Similar morphology findings have been shown at younger ages, thus the fundus results persist into young adulthood.

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Lind, AlexandraDepartment of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden (author)
Ovik, TitusDepartment of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden (author)
Aring, EvaDepartment of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden; Department of Ophthalmology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden (author)
Popovic, ZoranDepartment of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden (author)
Dahlgren, JovannaDepartment of Pediatrics, Göteborgs universitet, Institutionen for kliniska vetenskaper, Göteborg, Sweden (author)
Andersson Grönlund, Marita,1959-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden; Department of Ophthalmology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)mtad (author)
Department of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, SwedenDepartment of Clinical Neuroscience, Göteborgs universitet Institutionen for neurovetenskap och fysiologi, Göteborg, Sweden; Department of Ophthalmology, Region Västra Götaland, Sahlgrenska University Hospital, Gothenburg, Sweden (creator_code:org_t)

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In:Investigative Ophthalmology and Visual Science: Association for Research in Vision and Ophthalmology64:80146-04041552-5783

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