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Hippocampal subfiel...
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Andersson, P.,1992-Center for Life-span Developmental Research (LEADER), School of Behavioral, Social and Legal Sciences, Örebro University, Sweden
(author)
Hippocampal subfield volumes contribute to working memory interference control in aging : Evidence from longitudinal associations over 5 years
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Elsevier,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-109960
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-109960URI
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https://doi.org/10.1016/j.ynirp.2023.100189DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-216196URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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In memory, familiar but no longer relevant information may disrupt encoding and retrieval of to-be-learned information. While it has been demonstrated that the ability to resolve proactive interference (PI) in working memory (WM) is reduced in aging, the neuroanatomical components of this decline have yet to be determined. Hippocampal (HC) involvement in age-related decline in control of PI is currently not known. In particular, the association between HC subfield volumes and control of PI in WM has not been examined previously. Here we investigate the associations between mean level and 5-year trajectories of gray matter subfield volumes and PI in WM across the adult life span (N = 157). Longitudinal analyses over 5-years across all participants revealed that reduced volume in the subiculum was related to impaired control of PI. Age-stratified analyses showed that this association was most pronounced in older adults. Furthermore, we found that in older adults the effect of age on PI was mediated by GM volume in the HC. The current results show that HC volume is associated with the ability to control PI in WM, and that these associations are modulated by age.
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Samrani, GeorgeUmeå universitet,Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB),Aging Research Center (ARC), Karolinska Institute and Stockholm University, Sweden(Swepub:umu)gesa0002
(author)
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Andersson, MicaelUmeå universitet,Institutionen för strålningsvetenskaper,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)mian0001
(author)
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Persson, J.,1971-Örebro universitet,Institutionen för beteende-, social- och rättsvetenskap,Center for Life-span Developmental Research (LEADER), School of Behavioral, Social and Legal Sciences, Örebro University, Sweden; Aging Research Center (ARC), Karolinska Institute and Stockholm University, Sweden(Swepub:oru)jspn
(author)
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Center for Life-span Developmental Research (LEADER), School of Behavioral, Social and Legal Sciences, Örebro University, SwedenInstitutionen för strålningsvetenskaper
(creator_code:org_t)
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In:Neuroimage: Reports: Elsevier3:42666-9560
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