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  • Pellat, A.Gastroenterology and digestive oncology Department, Hôpital Cochin, Paris, France (författare)

Comprehensive mapping review of real-world evidence publications focusing on targeted therapies in solid tumors : A collaborative work from ESMO real-world data and Digital Health Working Group

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Elsevier,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-110156
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110156URI
  • https://doi.org/10.1016/j.annonc.2023.09.2643DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154265037URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: A growing body of real-world evidence (RWE) aims to better reflect outcomes of cancer patients treated in real-world settings. We aimed to conduct a first comprehensive mapping review of the RWE produced over the past 3 years in terms of tumor type, treatment strategies, setting, and data sources, focusing on targeted therapies (TT) in solid tumors.Methods: We conducted a systematic review in PubMed of RWE studies published between 01/2020 and 12/2022. We identified non-interventional studies using observational data, focusing on solid tumors exposure to targeted therapies, excluding immunotherapies. Abstract and full-text screening were performed by 11 independent reviewers.Results: A total of 7,774 publications were retrieved with 1,251 considered eligible and extracted. The number of publications per year progressively increased during this period (328 in 2020; 421 in 2021; 502 in 2022). Most studies (50%) were performed in Asia, followed by Europe (25%) and North America (17%). Only 8% of studies had patients treated in more than one country. Treatment effectiveness and safety were assessed in 71% and 42% of studies respectively. Main data sources were medical records.Conclusions: RWE publications on TT for solid tumors are heterogeneous and mostly rely on retrospective data such as medical records. Population-based and international studies are rare. Collaborative efforts towards international representativeness and the use of routinely collected and/or standardized data sources must be encouraged to increase the relevance and future quality of publications and their potential impact on oncology practice.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Grinda, T.Medical Oncology Dept., Institut Gustave Roussy, Villejuif, France (författare)
  • Prelaj, A.Department of Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Cresta, P.Medical Oncology Dept., VHIO - Vall d’Hebron Institute of Oncology, Barcelona, Spain (författare)
  • Valachis, A,1984-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Dpt. of Oncology(Swepub:oru)asvs (författare)
  • Zerdes, I.Oncology-Pathology Department, Karolinska Institutet - Bioclinicum, Solna, Sweden (författare)
  • Branco, D. MartinsAcademic Trials Promoting Team (ATPT), Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), Institut Jules Bordet, Brussels, Belgium (författare)
  • Provenzano, L.Department of Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Spagnoletti, A.Department of Medical Oncology, Fondazione IRCCS - Istituto Nazionale dei Tumori, Milan, Italy (författare)
  • Marta, G. NaderAcademic Trials Promoting Team (ATPT), Université Libre de Bruxelles (ULB), Hôpital Universitaire de Bruxelles (HUB), Institut Jules Bordet, Brussels, Belgium (författare)
  • Wilson, B.Department of Oncology, Queen's University, Kingston ON, Canada (författare)
  • Montemurro, F.Investigative Clinical Oncology dept., IRCCS - Istituto di Candiolo - FPO, Turin, Italy (författare)
  • Castelo-Branco, L.Scientific and Medical Division, ESMO - European Society for Medical Oncology, Lugano, Switzerland (författare)
  • Pentheroudakis, G.Scientific and Medical Division, ESMO - European Society for Medical Oncology, Lugano, Switzerland (författare)
  • Delaloge, S.Breast Oncology Department, Institut Gustave Roussy, Villejuif, France (författare)
  • Koopman, M.Medical Oncology Department, UMC - University Medical Center Utrecht, Utrecht, Netherlands (författare)
  • Gastroenterology and digestive oncology Department, Hôpital Cochin, Paris, FranceMedical Oncology Dept., Institut Gustave Roussy, Villejuif, France (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Annals of Oncology: Elsevier34:Suppl. 2, s. S925-S9250923-75341569-8041

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