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Short duration of b...
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Holmberg, HannaDivision of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden
(författare)
Short duration of breast-feeding as a risk-factor for beta-cell autoantibodies in 5-year-old children from the general population
- Artikel/kapitelEngelska2007
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Cambridge University Press,2007
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:oru-110293
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110293URI
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https://doi.org/10.1017/S0007114507210189DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Breast-feeding has been suggested to have a protective effect against the development of type 1 diabetes. In the present study, we investigated the relation between duration of breast-feeding and beta-cell autoantibodies in 5-year-old non-diabetic children who participated in a prospective population-based follow-up study (the All Babies in Southeast Sweden study). Autoantibodies to insulin (IAA), glutamic acid decarboxylase (GADA) and the protein tryosine phosphatase-like IA-2 (IA-2A) were measured by radiobinding assays. A short duration of total breast-feeding was associated with an increased risk of GADA and/or IAA above the ninety-fifth percentile at 5 years of age (OR 2.09, 95% CI 1.45, 3.02; P<0.000) as well as with an increased risk of IAA above the ninety-fifth percentile at this age (OR 2.89, 95% CI 1.81, 4.62, P<0.000). A short duration of exclusive breast-feeding was associated with an increased risk of GADA, IAA and/or IA-2A above the ninety-ninth percentile (OR 2.01, 95% CI 1.08, 3.73; P=0.028) as well as with an increased risk of IA-2A above the ninety-ninth percentile (OR 3.50, 95% CI 1.38, 8.92, P=0.009) at 5 years of age. An early introduction of formula was associated with an increased risk of GADA, IAA and/or IA-2A above the ninety-ninth percentile (OR 1.84, 95% CI 1.01, 3.37; P=0.047) at 5 years of age. The positive association between a short duration of both total and exclusive breast-feeding, as well as an early introduction of formula, and positivity for beta-cell autoantibodies in children from the general population suggest that breast-feeding modifies the risk of beta-cell autoimmunity, even years after finishing breast-feeding.
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Wahlberg, Jeanette,1969-Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden(Swepub:oru)jewg
(författare)
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Vaarala, OutiDivision of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden; Department of Viral Diseases and Immunology, Laboratory for Immunobiology, National Public Health Institute, Helsinki, Finland
(författare)
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Ludvigsson, JohnnyDivision of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden
(författare)
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ABIS Study Group, -
(bidragsgivare)
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Division of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, SwedenDivision of Paediatrics and Diabetes Research Centre, Department of Molecular and Clinical Medicine, Linköpings Universitet, Linköping, Sweden; Department of Viral Diseases and Immunology, Laboratory for Immunobiology, National Public Health Institute, Helsinki, Finland
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:British Journal of Nutrition: Cambridge University Press97:1, s. 111-1160007-11451475-2662
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