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Sökning: onr:"swepub:oai:DiVA.org:oru-110346" > Altered biomarkers ...

  • Saevik, Ase BjorvatnDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway,Univ Bergen, Norway; Univ Bergen, Norway (författare)

Altered biomarkers for cardiovascular disease and inflammation in autoimmune Addison's disease - a cross-sectional study

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • Bioscientifica,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-110346
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110346URI
  • https://doi.org/10.1093/ejendo/lvad136DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-217965URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154000224URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198960URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Research Council of NorwayNovo Nordisk FoundationInternal Medicine Association of NorwayUniversity of BergenWestern Regional Health AuthoritiesDepartment of Medicine and Hormone LaboratoryHaukeland University HospitalStockholm County CouncilKarolinska Institutet
  • Funding Agencies|Research Council of Norway [288022]; Novo Nordisk Foundation [NNF18OC0034130]; Internal Medicine Association of Norway; University of Bergen; Western Regional Health Authorities; Department of Medicine and Hormone Laboratory , Haukeland University Hospital; Stockholm County Council; Karolinska Institutet
  • Objective: Increased prevalence of cardiovascular disease has been reported in autoimmune Addisons disease (AAD), but pathomechanisms are poorly understood.Design: Cross-sectional study.Methods: We compared serum levels of 177 cardiovascular and inflammatory biomarkers in 43 patients with AAD at >18-h glucocorticoid withdrawal and 43 matched controls, overall and stratified for sex. Biomarker levels were correlated with the frequency of adrenal crises and quality of life (QoL) by AddiQoL-30. Finally, we investigated changes in biomarker levels following 250 mu g tetracosactide injection in patients without residual adrenocortical function (RAF) to explore glucocorticoid-independent effects of high ACTH.Results: Nineteen biomarkers significantly differed between patients with AAD and controls; all but 1 (ST1A1) were higher in AAD. Eight biomarkers were significantly higher in female patients compared with controls (IL6, MCP1, GAL9, SPON2, DR4, RAGE, TNFRSF9, and PGF), but none differed between male patients and controls. Levels of RAGE correlated with the frequency of adrenal crises (r = 0.415, P = .006) and AddiQoL-30 scores (r = -0.347, P = .028) but not after correction for multiple testing. PDL2 and leptin significantly declined 60 min after injection of ACTH in AAD without RAF (-0.15 normalized protein expression [NPX], P = .0001, and -0.25 NPX, P = .0003, respectively).Conclusions: We show that cardiovascular and inflammatory biomarkers are altered in AAD compared with controls, particularly in women. RAGE might be a marker of disease severity in AAD, associated with more adrenal crises and reduced QoL. High ACTH reduced PDL2 and leptin levels in a glucocorticoid-independent manner but the overall effect on biomarker profiles was small.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ueland, GretheDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway (författare)
  • Akerman, Anna-KarinDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Örebro University Hospital, Örebro, Sweden,Karolinska Inst, Sweden; Orebro Univ Hosp, Sweden (författare)
  • Methlie, PaalDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway,Univ Bergen, Norway; Haukeland Hosp, Norway (författare)
  • Quinkler, MarcusPractice for Endocrinology and Nephrology, Endocrinology in Charlottenburg, Berlin, Germany,Endocrinol Charlottenburg, Germany (författare)
  • Jorgensen, Anders PalmstromDepartment of Endocrinology, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway (författare)
  • Hoybye, CharlotteDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden; Karolinska Univ Hosp, Sweden (författare)
  • Wahlberg, JeanetteLinköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Endokrinmedicinska kliniken(Swepub:liu)jeawa98 (författare)
  • Nedrebo, Bjorn GunnarDepartment of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway (författare)
  • Dahle, Anne LiseDepartment of Internal Medicine, Haugesund Hospital, Haugesund, Norway,Haugesund Hosp, Norway (författare)
  • Carlsen, SiriDepartment of Endocrinology, Stavanger University Hospital, Stavanger, Norway,Stavanger Univ Hosp, Norway (författare)
  • Tomkowicz, AnetaDepartment of Medicine, Sørlandet Hospital, Kristiansand, Norway,Sorlandet Hosp, Norway (författare)
  • Sollid, Stina ThereseDepartment of Medicine, Drammen Hospital, Vestre Viken Health Trust, Drammen, Norway,Drammen Hosp, Norway (författare)
  • Nermoen, IngridDepartment of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway (författare)
  • Gronning, KajaDepartment of Endocrinology, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Norway (författare)
  • Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden(Swepub:umu)perdat96 (författare)
  • Grimnes, GuriDivision of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; Tromsø Endocrine Research Group, Department of Clinical Medicine, UiT the Arctic University of Norway, Tromsø, Norway,Univ Hosp North Norway, Norway; UiT Arctic Univ Norway, Norway (författare)
  • Skov, JakobDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden,Karolinska Inst, Sweden (författare)
  • Finnes, TrineSection of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway (författare)
  • Valland, Susanna F.Section of Endocrinology, Innlandet Hospital Trust, Hamar, Norway,Innlandet Hosp Trust, Norway (författare)
  • Wahlberg, Jeanette,1969-Linköping University, Linköping, Sweden(Swepub:oru)jewg (författare)
  • Holte, Synnove EmblemDepartment of Medicine, Sørlandet Hospital, Arendal, Norway,Sorlandet Hosp, Norway (författare)
  • Kampe, OlleK.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Karolinska Inst, Sweden (författare)
  • Bensing, SophieDepartment of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Department of Endocrinology, Karolinska University Hospital, Stockholm, Sweden,Karolinska Inst, Sweden (författare)
  • Husebye, Eystein SverreDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden (författare)
  • Oksnes, MarianneDepartment of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, Norway; Department of Medicine, Haukeland University Hospital, Bergen, Norway; Department of Medicine (Solna), Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden,Univ Bergen, Norway; Haukeland Hosp, Norway; Karolinska Inst, Sweden (författare)
  • Department of Clinical Science, University of Bergen, Bergen, Norway; K.G. Jebsen Center for Autoimmune Disorders, University of Bergen, Bergen, NorwayUniv Bergen, Norway; Univ Bergen, Norway (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Journal of Endocrinology: Bioscientifica189:4, s. 438-4470804-46431479-683X

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