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Vaccinations may in...
Vaccinations may induce diabetes-related autoantibodies in one-year-old children
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- Wahlberg, Jeanette, 1969- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Fredriksson, Jenny, 1977- (author)
- Linköpings universitet,Pediatrik,Hälsouniversitetet
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- Vaarala, Outi (author)
- Linköpings universitet,Hälsouniversitetet,Pediatrik
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- Ludvigsson, Johnny (author)
- Östergötlands Läns Landsting,Linköpings universitet,Hälsouniversitetet,Pediatrik,Barn- och ungdomskliniken i Linköping,Barn
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ABIS Study Group, - (contributor)
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(creator_code:org_t)
- Wiley-Blackwell Publishing Inc. 2003
- 2003
- English.
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In: Annals of the New York Academy of Sciences. - : Wiley-Blackwell Publishing Inc.. - 0077-8923 .- 1749-6632. ; 1005:1, s. 404-408
- Related links:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Subject headings
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- Vaccinations have been discussed as one among many environmental candidates contributing to the immune process that later may lead to type 1 diabetes. ABIS (All Babies in Southeast Sweden) is a prospective cohort study following a nonselected birth cohort of general population. In a randomly selected sample collection from 4400 children, GADA and IA-2A have been determined at the age of 1 year. The information on vaccinations was collected from questionnaires answered by the parents and was related to β cell autoantibodies. When studying the induction of autoantibodies using the autoantibody level of 90th percentile as cutoff level, hemophdus influenza B (HIB) vaccination appeared to be a risk factor for IA-2A [OR 5.9 (CI 1.4-24.4; p = 0.01)] and for GADA [OR 3.4 (CI 1.1-10.8; p = 0.04)] in logistic regression analyses. Furthermore, the titers of IA-2A were significantly higher (p < 0.01 in Mann-Whitney test) in those children who had got HIB vaccination. When 99th percentile was used as cutoff to identify the children at risk of type 1 diabetes, BCG vaccination was associated with increased prevalence of IA-2A (p < 0.01). We conclude that HIB vaccination may have an unspecific stimulatory polyclonal effect increasing the production of GADA and IA-2A. This might be of importance under circumstances when the β cell-related immune response is activated by other mechanisms.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- ABIS
- children
- diabetes
- autoantibodies
- BCG vaccination
- HIB vaccination
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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