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COVID-19 Vaccination-Related Delayed Adverse Events among Patients with Systemic Lupus Erythematosus

Dey, Mrinalini (författare)
Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UK
Doskaliuk, Bohdana (författare)
Department of Pathophysiology, Ivano-Frankivsk National Medical University, 76018 Ivano-Frankivsk, Ukraine
Lindblom, Julius (författare)
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
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Nikiphorou, Elena (författare)
Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UK; Rheumatology Department, King's College Hospital, London, UK
Wincup, Chris (författare)
Rheumatology Department, King's College Hospital, London, UK
Fathima, Madiha (författare)
Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden
Saha, Sreoshy (författare)
Mymensingh Medical College, Mymensingh, Bangladesh
Shaharir, Syahrul Sazliyana (författare)
Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia
Katchamart, Wanruchada (författare)
Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10100, Thailand
Goo, Phonpen Akarawatcharangura (författare)
Department of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand
Traboco, Lisa (författare)
Department of Medicine, Section of Rheumatology, St. Luke's Medical Center-Global City, Taguig, Philippines
Chen, Yi-Ming (författare)
Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan
Kadam, Esha (författare)
Seth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India
Lilleker, James B. (författare)
Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK
Nune, Arvind (författare)
Southport and Ormskirk Hospital NHS Trust, Southport, UK
Pauling, John D. (författare)
Bristol Medical School Translational Health Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, North Bristol NHS Trust, Bristol, UK
Agarwal, Vishwesh (författare)
Mahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India
Dey, Dzifa (författare)
Rheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Korle-Bu, Accra, Ghana
Toro Gutierrez, Carlos Enrique (författare)
Reference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Cali 760046, Colombia
Caballero, Carlo Vinicio (författare)
Department of Medicine, Hospital Universidad del Norte, Barranquilla, Colombia
Chinoy, Hector (författare)
Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK
Aggarwal, Rohit (författare)
Division of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, USA
Agarwal, Vikas (författare)
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
Gupta, Latika (författare)
Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK; Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK
Parodis, Ioannis, 1981- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Covad Study Group, - (bidragsgivare)
Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand
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 (creator_code:org_t)
MDPI, 2023
2023
Engelska.
Ingår i: Journal of Clinical Medicine. - : MDPI. - 2077-0383. ; 12:24
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: The safety profile of COVID-19 vaccination is well documented, but hesitancy among people with immune-mediated inflammatory diseases, often immunocompromised, remains high, partially due to a scarcity of data on safety over a longer term. We herein aimed to assess delayed adverse events (DAEs) occurring >7 days after COVID-19 vaccination in systemic lupus erythematosus (SLE) versus other rheumatic autoimmune diseases (rAIDs), non-rheumatic AIDs (nrAIDs), and healthy controls (HCs).METHODS: Self-reported data were captured within the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 online survey, which comprised >150 centres and responses from 106 countries, between February and June 2022. Logistic regression analysis adjusting for important confounders (age, sex, ethnicity) was used to compare groups.RESULTS: Of 7203 eligible individuals, 882 (12.2%) patients had SLE, 3161 (43.9%) patients had rAIDs, 426 (5.9%) patients had nrAIDs, and 2734 (38.0%) were HCs. SLE patients had a median age of 39 years (IQR: 31-50); 93.7% were women. SLE patients reported, more frequently, major DAEs (OR: 1.6; 95% CI: 1.2-2.0; p = 0.001) and hospitalisation (OR: 2.2; 95% CI: 1.4-3.4; p < 0.001) compared to HCs, severe rashes (OR: 2.4; 95% CI: 1.3-4.2; p = 0.004) compared to people with rAIDS, and hospitalisation (OR: 2.3; 95% CI: 1.1-4.9; p = 0.029) as well as several minor DAEs compared to people with nrAIDs. Differences were observed between vaccines in terms of frequency of major DAEs and hospitalisations, with the latter seen more frequently in patients receiving the Moderna vaccine. People with SLE with no autoimmune multimorbidity less frequently reported overall minor DAEs compared to SLE patients with comorbid nrAIDs (OR: 0.5; 95% CI: 0.3-1.0; p = 0.036).CONCLUSION: Hospitalisations post-vaccination were more frequent in SLE patients than in HCs. Monitoring of SLE patients following COVID-19 vaccination can help in identifying DAEs early, informing patients about expected DAEs, and supporting patients, especially those with autoimmune multimorbidity.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)

Nyckelord

COVID-19
delayed adverse events
systemic lupus erythematosus
vaccines

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