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  • Dey, MrinaliniCentre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UK (författare)

COVID-19 Vaccination-Related Delayed Adverse Events among Patients with Systemic Lupus Erythematosus

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • MDPI,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-110604
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110604URI
  • https://doi.org/10.3390/jcm12247542DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:154524990URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • IP is supported by grants from the Swedish Rheumatism Association (R-969696), King Gustaf V's 80-year Foundation (FAI-2020-0741), Swedish Society of Medicine (SLS-974449), Nyckel-fonden (OLL-974804), Professor Nanna Svartz Foundation (2021-00436), Ulla and Roland Gustafsson Foundation (2021-26), Region Stockholm (FoUI-955483), and Karolinska Institutet.
  • BACKGROUND: The safety profile of COVID-19 vaccination is well documented, but hesitancy among people with immune-mediated inflammatory diseases, often immunocompromised, remains high, partially due to a scarcity of data on safety over a longer term. We herein aimed to assess delayed adverse events (DAEs) occurring >7 days after COVID-19 vaccination in systemic lupus erythematosus (SLE) versus other rheumatic autoimmune diseases (rAIDs), non-rheumatic AIDs (nrAIDs), and healthy controls (HCs).METHODS: Self-reported data were captured within the COVID-19 Vaccination in Autoimmune Diseases (COVAD)-2 online survey, which comprised >150 centres and responses from 106 countries, between February and June 2022. Logistic regression analysis adjusting for important confounders (age, sex, ethnicity) was used to compare groups.RESULTS: Of 7203 eligible individuals, 882 (12.2%) patients had SLE, 3161 (43.9%) patients had rAIDs, 426 (5.9%) patients had nrAIDs, and 2734 (38.0%) were HCs. SLE patients had a median age of 39 years (IQR: 31-50); 93.7% were women. SLE patients reported, more frequently, major DAEs (OR: 1.6; 95% CI: 1.2-2.0; p = 0.001) and hospitalisation (OR: 2.2; 95% CI: 1.4-3.4; p < 0.001) compared to HCs, severe rashes (OR: 2.4; 95% CI: 1.3-4.2; p = 0.004) compared to people with rAIDS, and hospitalisation (OR: 2.3; 95% CI: 1.1-4.9; p = 0.029) as well as several minor DAEs compared to people with nrAIDs. Differences were observed between vaccines in terms of frequency of major DAEs and hospitalisations, with the latter seen more frequently in patients receiving the Moderna vaccine. People with SLE with no autoimmune multimorbidity less frequently reported overall minor DAEs compared to SLE patients with comorbid nrAIDs (OR: 0.5; 95% CI: 0.3-1.0; p = 0.036).CONCLUSION: Hospitalisations post-vaccination were more frequent in SLE patients than in HCs. Monitoring of SLE patients following COVID-19 vaccination can help in identifying DAEs early, informing patients about expected DAEs, and supporting patients, especially those with autoimmune multimorbidity.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Doskaliuk, BohdanaDepartment of Pathophysiology, Ivano-Frankivsk National Medical University, 76018 Ivano-Frankivsk, Ukraine (författare)
  • Lindblom, JuliusDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden (författare)
  • Nikiphorou, ElenaCentre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UK; Rheumatology Department, King's College Hospital, London, UK (författare)
  • Wincup, ChrisRheumatology Department, King's College Hospital, London, UK (författare)
  • Fathima, MadihaDivision of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden (författare)
  • Saha, SreoshyMymensingh Medical College, Mymensingh, Bangladesh (författare)
  • Shaharir, Syahrul SazliyanaFaculty of Medicine, Universiti Kebangsaan Malaysia, Cheras, Kuala Lumpur, Malaysia (författare)
  • Katchamart, WanruchadaDivision of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10100, Thailand (författare)
  • Goo, Phonpen AkarawatcharanguraDepartment of Medicine, Queen Savang Vadhana Memorial Hospital, Chonburi, Thailand (författare)
  • Traboco, LisaDepartment of Medicine, Section of Rheumatology, St. Luke's Medical Center-Global City, Taguig, Philippines (författare)
  • Chen, Yi-MingDivision of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan (författare)
  • Kadam, EshaSeth Gordhandhas Sunderdas Medical College and King Edwards Memorial Hospital, Mumbai, Maharashtra, India (författare)
  • Lilleker, James B.Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Manchester Centre for Clinical Neurosciences, Salford Royal NHS Foundation Trust, Salford, UK (författare)
  • Nune, ArvindSouthport and Ormskirk Hospital NHS Trust, Southport, UK (författare)
  • Pauling, John D.Bristol Medical School Translational Health Sciences, University of Bristol, Bristol, UK; Department of Rheumatology, North Bristol NHS Trust, Bristol, UK (författare)
  • Agarwal, VishweshMahatma Gandhi Mission Medical College, Navi Mumbai, Maharashtra, India (författare)
  • Dey, DzifaRheumatology Unit, Department of Medicine and Therapeutics, University of Ghana Medical School, College of Health Sciences, Korle-Bu, Accra, Ghana (författare)
  • Toro Gutierrez, Carlos EnriqueReference Center for Osteoporosis, Rheumatology and Dermatology, Pontifica Universidad Javeriana Cali, Cali 760046, Colombia (författare)
  • Caballero, Carlo VinicioDepartment of Medicine, Hospital Universidad del Norte, Barranquilla, Colombia (författare)
  • Chinoy, HectorDivision of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Department of Rheumatology, Salford Royal Hospital, Northern Care Alliance NHS Foundation Trust, Salford, UK (författare)
  • Aggarwal, RohitDivision of Rheumatology and Clinical Immunology, University of Pittsburgh School of Medicine, Pittsburgh, USA (författare)
  • Agarwal, VikasDepartment of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India (författare)
  • Gupta, LatikaDivision of Musculoskeletal and Dermatological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK; Department of Rheumatology, Royal Wolverhampton Hospitals NHS Trust, Wolverhampton, UK; Department of Rheumatology, City Hospital, Sandwell and West Birmingham Hospitals NHS Trust, Birmingham, UK (författare)
  • Parodis, Ioannis,1981-Örebro universitet,Institutionen för medicinska vetenskaper,Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden; Department of Rheumatology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden(Swepub:oru)isps (författare)
  • Covad Study Group, -Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand (bidragsgivare)
  • Centre for Rheumatic Diseases, King's College London, Weston Education Centre, Cutcombe Road, London, UKDepartment of Pathophysiology, Ivano-Frankivsk National Medical University, 76018 Ivano-Frankivsk, Ukraine (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Clinical Medicine: MDPI12:242077-0383

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