Sökning: WFRF:(Salihovic Samira 1985 ) >
Immunotoxic, genoto...
Immunotoxic, genotoxic, and endocrine disrupting impacts of polyamide microplastic particles and chemicals
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- Alijagic, Andi, 1992- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden; School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Man-Technology-Environment Research Center (MTM)
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- Kotlyar, Oleksandr, 1982- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM); Centre for Applied Autonomous Sensor Systems (AASS); Mobile Robotics and Olfaction Lab (MRO)
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- Larsson, Maria, 1975- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Hedbrant, Alexander, Ph.D, 1987- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Eriksson, Ulrika, 1972- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)
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- Karlsson, Patrik, 1973- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik
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- Persson, Alexander, 1978- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Scherbak, Nikolai, 1967- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)
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- Färnlund, Kim (författare)
- AMEXCI AB, Karlskoga, Sweden
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- Engwall, Magnus, 1965- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Man-Technology-Environment Research Center (MTM)
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- Särndahl, Eva, 1963- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
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Ingår i: Environment International. - : Elsevier. - 0160-4120 .- 1873-6750. ; 183
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Due to their exceptional properties and cost effectiveness, polyamides or nylons have emerged as widely used materials, revolutionizing diverse industries, including industrial 3D printing or additive manufacturing (AM). Powder-based AM technologies employ tonnes of polyamide microplastics to produce complex components every year. However, the lack of comprehensive toxicity assessment of particulate polyamides and polyamide-associated chemicals, especially in the light of the global microplastics crisis, calls for urgent action. This study investigated the physicochemical properties of polyamide-12 microplastics used in AM, and assessed a number of toxicity endpoints focusing on inflammation, immunometabolism, genotoxicity, aryl hydrocarbon receptor (AhR) activation, endocrine disruption, and cell morphology. Specifically, microplastics examination by means of field emission scanning electron microscopy revealed that work flow reuse of material created a fraction of smaller particles with an average size of 1-5 µm, a size range readily available for uptake by human cells. Moreover, chemical analysis by means of gas chromatography high-resolution mass spectrometry detected several polyamide-associated chemicals including starting material, plasticizer, thermal stabilizer/antioxidant, and migrating slip additive. Even if polyamide particles and chemicals did not induce an acute inflammatory response, repeated and prolonged exposure of human primary macrophages disclosed a steady increase in the levels of proinflammatory chemokine Interleukin-8 (IL-8/CXCL-8). Moreover, targeted metabolomics disclosed that polyamide particles modulated the kynurenine pathway and some of its key metabolites. The p53-responsive luciferase reporter gene assay showed that particles per se were able to activate p53, being indicative of a genotoxic stress. Polyamide-associated chemicals triggered moderate activation of AhR and elicited anti-androgenic activity. Finally, a high-throughput and non-targeted morphological profiling by Cell Painting assay outlined major sites of bioactivity of polyamide-associated chemicals and indicated putative mechanisms of toxicity in the cells. These findings reveal that the increasing use of polyamide microplastics may pose a potential health risk for the exposed individuals, and it merits more attention.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Additive manufacturing
- GC-HRMS
- High-throughput morphological profiling
- Metabolomics
- Nylon
- Plastic additives
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Alijagic, Andi, ...
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Kotlyar, Oleksan ...
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Larsson, Maria, ...
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Salihovic, Samir ...
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Hedbrant, Alexan ...
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Eriksson, Ulrika ...
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Karlsson, Patrik ...
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Persson, Alexand ...
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Scherbak, Nikola ...
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Färnlund, Kim
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Engwall, Magnus, ...
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Särndahl, Eva, 1 ...
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