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  • Björklund, FilipLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund, Sweden (författare)

Breathlessness and exercise performance to predict mortality in long-term oxygen therapy

  • Artikel/kapitelEngelska2023

Förlag, utgivningsår, omfång ...

  • European Respiratory Society,2023
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-110748
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-110748URI
  • https://doi.org/10.1183/13993003.congress-2023.PA3762DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:vet swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Background: Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality.Methods: This was a longitudinal, population-based study of patients who initiated LTOT between 2015-2018 in Sweden. Breathlessness was measured using the Dyspnea Exertion Scale, and exercise performance using the 30s-Sit-To-Stand test. Associations with overall and three-month mortality were analyzed using Cox-regression. Subgroup analyses were performed for patients with COPD and ILD respectively. The predictive capacity of models was assessed using a C-statistic.Results: A total of 441 patients (57.6% female, aged 75.4±8.3 years) were analyzed. Both breathlessness and exercise performance were independently associated with overall mortality in the crude models, but only exercise performance remained independently associated with overall mortality when models were adjusted for other predictors, when three-month mortality was analyzed, or when breathlessness and exercise capacity were analyzed concurrently. The multivariable model including exercise performance but not breathlessness provided a relatively high predictive capacity for overall mortality, C-statistic 0.756 (95% CI 0.702-0.810). Similar results were seen in the COPD and ILD subgroups.Conclusion: Exercise performance as measured by the 30s-STS may be useful to identify patients with higher mortality on LTOT for optimized management and follow-up.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Palm, AndreasUppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala, Sweden; Region of Gävleborg, Gävle Hospital, Centre for Research and Development, Gävle, Sweden (författare)
  • Gorani, Jwan AbdulrazakDepartment of Medicine, Blekinge Hospital, Karlskrona, Sweden (författare)
  • Ahmadi, ZainabLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund, Sweden (författare)
  • Sundh, Josefin,1972-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Respiratory Medicine(Swepub:oru)jnsh (författare)
  • Haglöw, Jenny TheorellUppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala, Sweden (författare)
  • Ljunggren, MirjamUppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala, Sweden (författare)
  • Grote, LudgerSahlgrenska University Hospital, Department of Pulmonary Medicine, Gothenburg, Sweden; Sahlgrenska Academy, Center for Sleep and Wake Disorders, Gothenburg, Sweden (författare)
  • Wadell, KarinUmeå University, Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå, Sweden (författare)
  • Ekström, MagnusLund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund, Sweden (författare)
  • Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Respiratory Medicine, Allergology, and Palliative Medicine, Lund, SwedenUppsala University, Department of Medical Sciences, Respiratory, Allergy and Sleep Research, Uppsala, Sweden; Region of Gävleborg, Gävle Hospital, Centre for Research and Development, Gävle, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Respiratory Journal: European Respiratory Society62:Suppl. 670903-19361399-3003

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