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A common variant as...
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Amundadottir, Laufey T.
(author)
A common variant associated with prostate cancer in European and African populations
- Article/chapterEnglish2006
Publisher, publication year, extent ...
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2006-05-07
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DeCODE Genet, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Pathol, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Urol, IS-101 Reykjavik, Iceland. Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA. Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA.Springer Science and Business Media LLC,2006
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printrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:oru-11091
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https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-11091URI
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https://doi.org/10.1038/ng1808DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-40719URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:1960547URI
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-13567URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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With the increasing incidence of prostate cancer, identifying common genetic variants that confer risk of the disease is important. Here we report such a variant on chromosome 8q24, a region initially identified through a study of Icelandic families. Allele -8 of the microsatellite DG8S737 was associated with prostate cancer in three case-control series of European ancestry from Iceland, Sweden and the US. The estimated odds ratio (OR) of the allele is 1.62 (P = 2.7 x 10(-11)). About 19% of affected men and 13% of the general population carry at least one copy, yielding a population attributable risk (PAR) of approximately 8%. The association was also replicated in an African American case-control group with a similar OR, in which 41% of affected individuals and 30% of the population are carriers. This leads to a greater estimated PAR (16%) that may contribute to higher incidence of prostate cancer in African American men than in men of European ancestry.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sulem, Patrick
(author)
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Gudmundsson, Julius
(author)
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Helgason, Agnar
(author)
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Baker, Adam
(author)
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Agnarsson, Bjarni A.
(author)
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Sigurdsson, Asgeir
(author)
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Benediktsdottir, Kristrun R.
(author)
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Cazier, Jean-Baptiste
(author)
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Sainz, Jesus
(author)
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Jakobsdottir, Margret
(author)
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Kostic, Jelena
(author)
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Magnusdottir, Droplaug N.
(author)
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Ghosh, Shyamali
(author)
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Agnarsson, Kari
(author)
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Birgisdottir, Birgitta
(author)
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Le Roux, Louise
(author)
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Olafsdottir, Adalheidur
(author)
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Blondal, Thorarinn
(author)
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Andresdottir, Margret
(author)
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Gretarsdottir, Olafia Svandis
(author)
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Bergthorsson, Jon T.
(author)
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Gudbjartsson, Daniel
(author)
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Gylfason, Arnaldur
(author)
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Thorleifsson, Gudmar
(author)
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Manolescu, Andrei
(author)
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Kristjansson, KristleifurKarolinska Institutet
(author)
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Geirsson, Gudmundur
(author)
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Isaksson, Helgi
(author)
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Douglas, Julie
(author)
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Johansson, Jan-ErikÖrebro universitet,Institutionen för klinisk medicin(Swepub:oru)jkjn
(author)
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Bälter, KatarinaKarolinska institutet, Sweden(Swepub:mdh)kbr01
(author)
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Wiklund, FredrikKarolinska Institutet
(author)
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Montie, James E.
(author)
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Yu, Xiaoying
(author)
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Suarez, Brian K.
(author)
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Ober, Carole
(author)
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Cooney, Kathleen A.
(author)
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Gronberg, HenrikUmeå universitet,Karolinska Institutet,Institutionen för strålningsvetenskaper
(author)
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Catalona, William J.
(author)
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Einarsson, Gudmundur V.
(author)
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Barkardottir, Rosa B.
(author)
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Gulcher, Jeffrey R.
(author)
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Kong, Augustine
(author)
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Thorsteinsdottir, Unnur
(author)
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Stefansson, Kari
(author)
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Karolinska InstitutetInstitutionen för klinisk medicin
(creator_code:org_t)
Related titles
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In:Nature GeneticsDeCODE Genet, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Pathol, IS-101 Reykjavik, Iceland. Univ Iceland, Landspitali Hosp, Dept Urol, IS-101 Reykjavik, Iceland. Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA. Orebro Univ Hosp, Dept Urol & Clin Med, Orebro, Sweden. Karolinska Inst, Dept Med Epidemiol & Biostat, SE-17177 Stockholm, Sweden. Univ Michigan, Dept Urol, Ann Arbor, MI 48109 USA. Northwestern Univ, Feinberg Sch Med, Dept Urol, Chicago, IL 60611 USA. Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA. Univ Chicago, Dept Human Genet, Chicago, IL 60637 USA. Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. : Springer Science and Business Media LLC38:6, s. 652-6581061-40361546-1718
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- By the author/editor
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Amundadottir, La ...
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Sulem, Patrick
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Gudmundsson, Jul ...
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Helgason, Agnar
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Baker, Adam
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Agnarsson, Bjarn ...
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Sigurdsson, Asge ...
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Benediktsdottir, ...
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Cazier, Jean-Bap ...
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Sainz, Jesus
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Jakobsdottir, Ma ...
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Kostic, Jelena
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Magnusdottir, Dr ...
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Ghosh, Shyamali
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Agnarsson, Kari
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Birgisdottir, Bi ...
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Le Roux, Louise
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Olafsdottir, Ada ...
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Blondal, Thorari ...
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Andresdottir, Ma ...
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Gretarsdottir, O ...
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Bergthorsson, Jo ...
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Gudbjartsson, Da ...
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Gylfason, Arnald ...
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Thorleifsson, Gu ...
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Manolescu, Andre ...
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Kristjansson, Kr ...
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Geirsson, Gudmun ...
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Isaksson, Helgi
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Douglas, Julie
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Johansson, Jan-E ...
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Bälter, Katarina
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Wiklund, Fredrik
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Montie, James E.
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Yu, Xiaoying
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Suarez, Brian K.
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Ober, Carole
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Cooney, Kathleen ...
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Gronberg, Henrik
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Catalona, Willia ...
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Einarsson, Gudmu ...
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Barkardottir, Ro ...
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Gulcher, Jeffrey ...
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Kong, Augustine
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Thorsteinsdottir ...
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Stefansson, Kari
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
- Articles in the publication
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Nature Genetics
- By the university
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Örebro University
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Mälardalen University
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Karolinska Institutet
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Umeå University