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All cause and cause...
All cause and cause specific mortality in obsessive-compulsive disorder : nationwide matched cohort and sibling cohort study
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- Fernández de la Cruz, Lorena (författare)
- Karolinska Institute,Karolinska Institutet
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- Isomura, Kayoko (författare)
- Karolinska Institute,Karolinska Institutet
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- Lichtenstein, Paul (författare)
- Karolinska Institute,Karolinska Institutet
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- Larsson, Henrik, 1975- (författare)
- Örebro University,Karolinska Institute,Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Kuja-Halkola, Ralf (författare)
- Karolinska Institute,Karolinska Institutet
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- Chang, Zheng (författare)
- Karolinska Institute,Karolinska Institutet
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- D'Onofrio, Brian M. (författare)
- Karolinska Institute,Karolinska Institutet,Indiana University
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- Brikell, Isabell (författare)
- Karolinska Institute,Karolinska Institutet,Aarhus University,University of Bergen
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- Rück, Christian (författare)
- Karolinska Institute,Karolinska Institutet
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- Sidorchuk, Anna (författare)
- Karolinska Institute,Karolinska Institutet
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- Mataix-Cols, David (författare)
- Karolinska Institute,Lund University,Lunds universitet,Karolinska Institutet,Innovations in pediatric mental health,Forskargrupper vid Lunds universitet,Lund University Research Groups,Stockholm Regional Council
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(creator_code:org_t)
- BMJ Publishing Group Ltd, 2024
- 2024
- Engelska.
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Ingår i: BMJ (Clinical Research Edition). - : BMJ Publishing Group Ltd. - 0959-8138 .- 1756-1833. ; 384
- Relaterad länk:
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https://doi.org/10.1...
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To estimate the risk of all cause and cause specific mortality in people with obsessive-compulsive disorder (OCD) compared with matched unaffected people from the general population and with their unaffected siblings. DESIGN: Population based matched cohort and sibling cohort study. SETTING: Register linkage in Sweden.PARTICIPANTS: Population based cohort including 61 378 people with OCD and 613 780 unaffected people matched (1:10) on sex, birth year, and county of residence; sibling cohort consisting of 34 085 people with OCD and 47 874 unaffected full siblings. Cohorts were followed up for a median time of 8.1 years during the period from 1 January 1973 to 31 December 2020. MAIN OUTCOME MEASURES: All cause and cause specific mortality.RESULTS: 4787 people with OCD and 30 619 unaffected people died during the study period (crude mortality rate 8.1 and 5.1 per 1000 person years, respectively). In stratified Cox proportional hazards models adjusted for birth year, sex, county, migrant status (born in Sweden versus abroad), and sociodemographic variables (latest recorded education, civil status, and family income), people with OCD had an increased risk of all cause mortality (hazard ratio 1.82, 95% confidence interval 1.76 to 1.89) and mortality due to natural causes (1.31, 1.27 to 1.37) and unnatural causes (3.30, 3.05 to 3.57). Among the natural causes of death, those due to endocrine, nutritional, and metabolic diseases, mental and behavioural disorders, and diseases of the nervous, circulatory, respiratory, digestive, and genitourinary systems were higher in the OCD cohort. Conversely, the risk of death due to neoplasms was lower in the OCD cohort compared with the unaffected cohort. Among the unnatural causes, suicide showed the highest hazard ratio, followed by accidents. The results were robust to adjustment for psychiatric comorbidities and familial confounding.CONCLUSIONS: Non-communicable diseases and external causes of death, including suicides and accidents, were major contributors to the risk of mortality in people with OCD. Better surveillance, prevention, and early intervention strategies should be implemented to reduce the risk of fatal outcomes in people with OCD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
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Fernández de la ...
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Isomura, Kayoko
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Lichtenstein, Pa ...
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Larsson, Henrik, ...
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Kuja-Halkola, Ra ...
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Chang, Zheng
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D'Onofrio, Brian ...
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Brikell, Isabell
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Rück, Christian
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Sidorchuk, Anna
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Mataix-Cols, Dav ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
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BMJ (Clinical Re ...
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BMJ
- Av lärosätet
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Örebro universitet
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Karolinska Institutet
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Lunds universitet