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  • Fernández de la Cruz, LorenaKarolinska Institute,Karolinska Institutet (författare)

All cause and cause specific mortality in obsessive-compulsive disorder : nationwide matched cohort and sibling cohort study

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • BMJ Publishing Group Ltd,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-111022
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111022URI
  • https://doi.org/10.1136/bmj-2023-077564DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238233033URI
  • https://lup.lub.lu.se/record/5bedb531-2142-4f7f-9957-9b6d8d35bf3dURI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • OBJECTIVE: To estimate the risk of all cause and cause specific mortality in people with obsessive-compulsive disorder (OCD) compared with matched unaffected people from the general population and with their unaffected siblings. DESIGN: Population based matched cohort and sibling cohort study. SETTING: Register linkage in Sweden.PARTICIPANTS: Population based cohort including 61 378 people with OCD and 613 780 unaffected people matched (1:10) on sex, birth year, and county of residence; sibling cohort consisting of 34 085 people with OCD and 47 874 unaffected full siblings. Cohorts were followed up for a median time of 8.1 years during the period from 1 January 1973 to 31 December 2020. MAIN OUTCOME MEASURES: All cause and cause specific mortality.RESULTS: 4787 people with OCD and 30 619 unaffected people died during the study period (crude mortality rate 8.1 and 5.1 per 1000 person years, respectively). In stratified Cox proportional hazards models adjusted for birth year, sex, county, migrant status (born in Sweden versus abroad), and sociodemographic variables (latest recorded education, civil status, and family income), people with OCD had an increased risk of all cause mortality (hazard ratio 1.82, 95% confidence interval 1.76 to 1.89) and mortality due to natural causes (1.31, 1.27 to 1.37) and unnatural causes (3.30, 3.05 to 3.57). Among the natural causes of death, those due to endocrine, nutritional, and metabolic diseases, mental and behavioural disorders, and diseases of the nervous, circulatory, respiratory, digestive, and genitourinary systems were higher in the OCD cohort. Conversely, the risk of death due to neoplasms was lower in the OCD cohort compared with the unaffected cohort. Among the unnatural causes, suicide showed the highest hazard ratio, followed by accidents. The results were robust to adjustment for psychiatric comorbidities and familial confounding.CONCLUSIONS: Non-communicable diseases and external causes of death, including suicides and accidents, were major contributors to the risk of mortality in people with OCD. Better surveillance, prevention, and early intervention strategies should be implemented to reduce the risk of fatal outcomes in people with OCD.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Isomura, KayokoKarolinska Institute (författare)
  • Lichtenstein, PaulKarolinska Institute (författare)
  • Larsson, Henrik,1975-Örebro University,Karolinska Institute,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden(Swepub:oru)hiln (författare)
  • Kuja-Halkola, RalfKarolinska Institute,Karolinska Institutet (författare)
  • Chang, ZhengKarolinska Institute,Karolinska Institutet (författare)
  • D'Onofrio, Brian M.Karolinska Institute,Indiana University (författare)
  • Brikell, IsabellKarolinska Institute,Aarhus University,University of Bergen (författare)
  • Rück, ChristianKarolinska Institute,Karolinska Institutet (författare)
  • Sidorchuk, AnnaKarolinska Institute,Karolinska Institutet (författare)
  • Mataix-Cols, DavidKarolinska Institute,Lund University,Lunds universitet,Innovations in pediatric mental health,Forskargrupper vid Lunds universitet,Lund University Research Groups,Stockholm Regional Council(Swepub:lu)da5182ma (författare)
  • Karolinska InstituteKarolinska Institutet (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:BMJ (Clinical Research Edition): BMJ Publishing Group Ltd3840959-81381756-1833
  • Ingår i:BMJ: BMJ Publishing Group Ltd3840959-8146

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