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Long-Term Effect of...
Long-Term Effect of Maintenance Electroconvulsive Therapy in Patients With Depression-Data From a Small Randomized Controlled Trial
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- Brus, Ole, 1982- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Clinical epidemiology and biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Cao, Yang, Associate Professor, 1972- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical epidemiology and biostatistics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- Carlborg, Andreas (författare)
- Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
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- Engström, Ingemar, 1952- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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- von Knorring, Lars (författare)
- Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden
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- Nordenskjöld, Axel, 1977- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,University Health Care Research Center, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2024
- 2024
- Engelska.
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Ingår i: Journal of ECT. - : Lippincott Williams & Wilkins. - 1095-0680 .- 1533-4112. ; 40:3, s. 169-172
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: This study aimed to compare the long-term effects of maintenance electroconvulsive therapy (M-ECT) with medication and medication only in patients with depression.METHODS: A randomized controlled trial of 1 year of M-ECT with medication or medication only investigated relapse/recurrence among 56 patients in remission after electroconvulsive therapy (ECT) for depression was conducted. The results of the first year are published already and showed a significant advantage of M-ECT with medication.The current study was a long-term follow-up. When the randomized treatment allocation ended, medication was continued in both groups but M-ECT was terminated. Patients were followed for up to 10 years via Swedish national registers until the study endpoint of a new psychiatric diagnosis as an inpatient, suicide, suspected suicide, or death of another cause. Time to relapse was compared between the M-ECT with medication group and the medication-only group using Kaplan-Meier estimates.RESULTS: The median follow-up time was 6.5 years for the M-ECT and medication group and 3.1 years for the medication-only group. One year after randomization 22 patients remained in the M-ECT and medication group, and 14 patients remained in the medication-only group. Relapse patterns between the treatment groups after the completion of M-ECT seemed to be similar according to visual inspection.CONCLUSIONS: This long-term follow-up study suggests that most of the benefit achieved during the treatment period with M-ECT is maintained over several years, but the small sample size, with accompanying large statistical imprecision, makes the results uncertain. More long-term studies of M-ECT are required.Trial registration: ClinicalTrials.gov identifier: NCT00627887.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
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- ref (ämneskategori)
- art (ämneskategori)
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