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Additional booster doses in patients with chronic lymphocytic leukemia induce humoral and cellular immune responses to SARS-CoV-2 similar to natural infection regardless ongoing treatments : A study by ERIC, the European Research Initiative on CLL

Campanella, A. (author)
Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
Capasso, A. (author)
Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
Heltai, S. (author)
IRCCS San Raffaele Hospital, Milan, Italy
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Taccetti, C. (author)
Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
Albi, E. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Herishanu, Y. (author)
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel; Tel Aviv University, Tel-Aviv, Israel
Haggenburg, S. (author)
Amsterdam UMC, Amsterdam, The Netherlands
Chatzikonstantinou, T. (author)
Centre for Research and Technology Hellas, Thessaloniki, Greece
Doubek, M. (author)
University Hospital Brno, Brno, Czech Republic
Kättström, Magdalena, 1974- (author)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Giannopoulos, K. (author)
Medical University of Lublin, Lublin, Poland
Simkovic, M. (author)
4th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
Moreno, C. (author)
Hospital de la Santa Creu I Sant Pau, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
Massaia, M. (author)
AO S.Croce e Carle, Cuneo, Italy; Turin University, Turin, Italy
Bumbea, H. (author)
University Emergency Hospital, Bucharest, Romania; University of Medicine and Pharmacy, Carol Davila, Bucharest, Romania
Alshemmari, S. (author)
Department of Medicine, Faculty of Medicine, Kuwait University, Safat, Kuwait
Ranghetti, P. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Perotta, E. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Martini, F. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Sant'Antonio, E. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Colia, M. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Combi, C. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Levi, S. (author)
Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
Kater, A. P. (author)
Amsterdam UMC, Amsterdam, The Netherlands
Hazenberg, M. (author)
Amsterdam UMC, Amsterdam, The Netherlands
Nijhof, I. S. (author)
Amsterdam UMC, Amsterdam, The Netherlands; St Antonius Hospital, Nieuwegein, The Netherlands
Hofsink, Q. (author)
Amsterdam UMC, Amsterdam, The Netherlands
Demosthenous, C. (author)
Centre for Research and Technology Hellas, Thessaloniki, Greece; Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Kotaskova, J. (author)
University Hospital Brno, Brno, Czech Republic; Central European Institute of Technology, Masaryk University, Brno, Czech Republic
Zaleska, J. (author)
Medical University of Lublin, Lublin, Poland
Vrbacky, F. (author)
4th Department of Internal Medicine - Haematology, Faculty of Medicine in Hradec Králové, University Hospital and Charles University in Prague, Hradec Kralove, Czech Republic
Raya, A. Mora (author)
Hospital de la Santa Creu I Sant Pau, Josep Carreras Leukaemia Research Institute, Barcelona, Spain
Bisogno, D. (author)
AO S.Croce e Carle, Cuneo, Italy
Tripoli, I. E. (author)
AO S.Croce e Carle, Cuneo, Italy; Turin University, Turin, Italy
Popov, V. M. (author)
Colentina Clinical Hospital, Bucharest, Romania
Roman, V. (author)
Center of Immunology Department, Stefan S. Nicolau Institute of Virology, Bucharest, Romania
Stavroyianni, N. (author)
Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece
Karypidou, M. (author)
Centre for Research and Technology Hellas, Thessaloniki, Greece
Scarano, E. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Locatelli, M. (author)
Laboratory Medicine Service, IRCCS San Raffaele Hospital, Milano, Italy
Frenquelli, M. (author)
IRCCS San Raffaele Hospital, Milan, Italy
Scarfò, L. (author)
Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
Stamatopoulos, K. (author)
Centre for Research and Technology Hellas, Thessaloniki, Greece
Ghia, P. (author)
Vita Salute San Raffaele University, Milan, Italy; IRCCS San Raffaele Hospital, Milan, Italy
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 (creator_code:org_t)
John Wiley & Sons, 2024
2024
English.
In: American Journal of Hematology. - : John Wiley & Sons. - 0361-8609 .- 1096-8652. ; 99:4, s. 745-750
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (other academic/artistic)
Abstract Subject headings
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  • Profound immune dysregulation and impaired response to the SARS-CoV-2 vaccine put patients with chronic lymphocytic leukemia (CLL) at risk of severe COVID-19. We compared humoral memory and T-cell responses after booster dose vaccination or breakthrough infection. (Green) Quantitative determination of anti-Spike specific antibodies. Booster doses increased seroconversion rate and antibody titers in all patient categories, ultimately generating humoral responses similar to those observed in the postinfection cohort. In detail, humoral response with overscale median antibody titers arose in >80% of patients in watch and wait, off-therapy in remission, or under treatment with venetoclax single-agent. Anti-CD20 antibodies and active treatment with BTK inhibitors (BTKi) represent limiting factors of humoral response, still memory mounted in ~40% of cases following booster doses or infection. (Blue) Evaluation of SARS-CoV-2-specific T-cell responses. Number of T-cell functional activation markers documented in each patient. The vast majority of patients, including those seronegative, developed T-cell responses, qualitatively similar between treatment groups or between vaccination alone and infection cases. These data highlight the efficacy of booster doses in eliciting T-cell immunity independently of treatment status and support the use of additional vaccination boosters to stimulate humoral immunity in patients on active CLL-directed treatments.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)

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vet (subject category)
art (subject category)

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