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Vaccine-Induced Ser...
Vaccine-Induced Seroreactivity Impacts the Accuracy of HIV Testing Algorithms in Sub-Saharan Africa : An Exploratory Study
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- Msafiri, Frank (författare)
- Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania; Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden
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- Manjate, Alice, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Faculdade de Medicina, Universidade Eduardo Mondlane, Maputo, Mozambique
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- Lindroth, Sarah (författare)
- School of Medical Sciences, Örebro University, Örebro, Sweden
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- Tembe, Nelson (författare)
- Instituto Nacional de Saúde, Maputo, Mozambique
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- Chissumba, Raquel Matavele (författare)
- Instituto Nacional de Saúde, Maputo, Mozambique
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- Cumbane, Victoria (författare)
- Instituto Nacional de Saúde, Maputo, Mozambique
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- Jani, Ilesh (författare)
- Instituto Nacional de Saúde, Maputo, Mozambique
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- Aboud, Said (författare)
- Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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- Lyamuya, Eligius (författare)
- Department of Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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- Andersson, Sören, 1957- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Public Health Agency of Sweden, Solna, Sweden
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- Nilsson, Charlotta (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2022-07-01
- 2022
- Engelska.
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Ingår i: Vaccines. - : MDPI. - 2076-393X. ; 10:7
- Relaterad länk:
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https://doi.org/10.3...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The detection of vaccine-induced HIV antibody responses by rapid diagnostic tests (RDTs) may confound the interpretation of HIV testing results. We assessed the impact of vaccine-induced seroreactivity (VISR) on the diagnosis of HIV in sub-Saharan Africa. Samples collected from healthy participants of HIVIS and TaMoVac HIV vaccine trials after the final vaccination were analyzed for VISR using HIV testing algorithms used in Mozambique and Tanzania that employ two sequential RDTs. The samples were also tested for VISR using Enzygnost HIV Integral 4 ELISA and HIV western blot assays. Antibody titers to subtype C gp140 were determined using an in-house enzyme-linked immunosorbent assay (ELISA). The frequency of VISR was 93.4% (128/137) by Enzygnost HIV Integral 4 ELISA, and 66.4% (91/137) by western blot assay (WHO interpretation). The proportion of vaccine recipients that would have been misdiagnosed as HIV-positive in Mozambique was half of that in Tanzania: 26.3% (36/137) and 54.0% (74/137), respectively, p < 0.0001. In conclusion, the HIV RDTs and algorithms assessed here will potentially misclassify a large proportion of the HIV vaccine recipients if no other test is used. Increased efforts are needed to develop differential serological or molecular tools for use at the point of care.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- HIV diagnostic algorithms
- HIV misdiagnosis
- vaccine-induced HIV antibodies
- vaccine-induced seroreactivity
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Vaccines
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Msafiri, Frank
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Manjate, Alice, ...
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Lindroth, Sarah
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Tembe, Nelson
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Chissumba, Raque ...
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Cumbane, Victori ...
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Jani, Ilesh
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Aboud, Said
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Lyamuya, Eligius
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Andersson, Sören ...
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Nilsson, Charlot ...
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Örebro universitet
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