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Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates

Hering, Bernhard J. (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Wijkstrom, Martin (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Graham, Melanie L. (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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Hårdstedt, Maria, 1971- (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Aasheim, Tor C. (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Jie, Tun (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Ansite, Jeffrey D. (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Nakano, Masahiko (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Cheng, Jane (författare)
Immerge BioTherapeutics, Inc., Massachusetts, USA
Li, Wei (författare)
Immerge BioTherapeutics, Inc., Massachusetts, USA
Moran, Kathleen (författare)
Immerge BioTherapeutics, Inc., Massachusetts, USA
Christians, Uwe (författare)
Department of Anesthesia, University of Colorado Health Sciences Center, Denver, Colorado, USA
Finnegan, Colleen (författare)
Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA
Mills, Charles D. (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Sutherland, David E. (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Bansal-Pakala, Pratima (författare)
Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
Murtaugh, Michael P. (författare)
Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA
Kirchhof, Nicole (författare)
Department of Veterinary Population Medicine, Veterinary Medical Center, University of Minnesota, St. Paul, Minnesota, USA
Schuurman, Henk-Jan (författare)
Immerge BioTherapeutics, Inc., Massachusetts, USA
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Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA Immerge BioTherapeutics, Inc, Massachusetts, USA (creator_code:org_t)
2006-02-19
2006
Engelska.
Ingår i: Nature Medicine. - : Nature Publishing Group. - 1078-8956 .- 1546-170X. ; 12:3, s. 301-303
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
NATURVETENSKAP  -- Biologi -- Immunologi (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Immunology (hsv//eng)

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