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Prolonged diabetes ...
Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates
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- Hering, Bernhard J. (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Wijkstrom, Martin (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Graham, Melanie L. (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Hårdstedt, Maria, 1971- (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Aasheim, Tor C. (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Jie, Tun (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Ansite, Jeffrey D. (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Nakano, Masahiko (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Cheng, Jane (författare)
- Immerge BioTherapeutics, Inc., Massachusetts, USA
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- Li, Wei (författare)
- Immerge BioTherapeutics, Inc., Massachusetts, USA
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- Moran, Kathleen (författare)
- Immerge BioTherapeutics, Inc., Massachusetts, USA
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- Christians, Uwe (författare)
- Department of Anesthesia, University of Colorado Health Sciences Center, Denver, Colorado, USA
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- Finnegan, Colleen (författare)
- Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA
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- Mills, Charles D. (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Sutherland, David E. (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Bansal-Pakala, Pratima (författare)
- Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA
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- Murtaugh, Michael P. (författare)
- Department of Veterinary and Biomedical Sciences, University of Minnesota, St. Paul, Minnesota, USA
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- Kirchhof, Nicole (författare)
- Department of Veterinary Population Medicine, Veterinary Medical Center, University of Minnesota, St. Paul, Minnesota, USA
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- Schuurman, Henk-Jan (författare)
- Immerge BioTherapeutics, Inc., Massachusetts, USA
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Diabetes Institute for Immunology and Transplantation, Department of Surgery, University of Minnesota, Minneapolis, Minnesota, USA Immerge BioTherapeutics, Inc, Massachusetts, USA (creator_code:org_t)
- 2006-02-19
- 2006
- Engelska.
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Ingår i: Nature Medicine. - : Nature Publishing Group. - 1078-8956 .- 1546-170X. ; 12:3, s. 301-303
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Cell-based diabetes therapy requires an abundant cell source. Here, we report reversal of diabetes for more than 100 d in cynomolgus macaques after intraportal transplantation of cultured islets from genetically unmodified pigs without Gal-specific antibody manipulation. Immunotherapy with CD25-specific and CD154-specific monoclonal antibodies, FTY720 (or tacrolimus), everolimus and leflunomide suppressed indirect activation of T cells, elicitation of non-Gal pig-specific IgG antibody, intragraft expression of proinflammatory cytokines and invasion of infiltrating mononuclear cells into islets.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
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Hering, Bernhard ...
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Wijkstrom, Marti ...
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Graham, Melanie ...
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Hårdstedt, Maria ...
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Aasheim, Tor C.
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Jie, Tun
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Ansite, Jeffrey ...
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Nakano, Masahiko
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Cheng, Jane
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Li, Wei
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Moran, Kathleen
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Christians, Uwe
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Finnegan, Collee ...
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Mills, Charles D ...
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Sutherland, Davi ...
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Bansal-Pakala, P ...
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Murtaugh, Michae ...
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Kirchhof, Nicole
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Schuurman, Henk- ...
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