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  • Hedberg, JakobKarolinska Institutet (författare)

Randomized controlled trial of nasogastric tube use after esophagectomy : study protocol for the kinetic trial

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-111663
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-111663URI
  • https://doi.org/10.1093/dote/doae010DOI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-201469URI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:155042099URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Study protocol
  • Funding Agencies|Swedish Cancer Foundation [CAN 2021/1086]
  • Esophagectomy is a complex and complication laden procedure. Despite centralization, variations in perioparative strategies reflect a paucity of evidence regarding optimal routines. The use of nasogastric (NG) tubes post esophagectomy is typically associated with significant discomfort for the patients. We hypothesize that immediate postoperative removal of the NG tube is non-inferior to current routines. All Nordic Upper Gastrointestinal Cancer centers were invited to participate in this open-label pragmatic randomized controlled trial (RCT). Inclusion criteria include resection for locally advanced esophageal cancer with gastric tube reconstruction. A pretrial survey was undertaken and was the foundation for a consensus process resulting in the Kinetic trial, an RCT allocating patients to either no use of a NG tube (intervention) or 5 days of postoperative NG tube use (control) with anastomotic leakage as primary endpoint. Secondary endpoints include pulmonary complications, overall complications, length of stay, health related quality of life. A sample size of 450 patients is planned (Kinetic trial: https://www.isrctn.com/ISRCTN39935085). Thirteen Nordic centers with a combined catchment area of 17 million inhabitants have entered the trial and ethical approval was granted in Sweden, Norway, Finland, and Denmark. All centers routinely use NG tube and all but one center use total or hybrid minimally invasive-surgical approach. Inclusion began in January 2022 and the first annual safety board assessment has deemed the trial safe and recommended continuation. We have launched the first adequately powered multi-center pragmatic controlled randomized clinical trial regarding NG tube use after esophagectomy with gastric conduit reconstruction.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Sundbom, MagnusDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden,Uppsala Univ, Sweden (författare)
  • Edholm, DavidLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US(Swepub:liu)daved38 (författare)
  • Aahlin, Eirik KjusDepartment of GI and HPB Surgery, Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway; Department of GI and HPB Surgery, University Hospital of Northern Norway, Tromsø, Norway,Univ Tromso, Norway; Univ Hosp Northern Norway, Norway (författare)
  • Szabo, Eva,PhD,1973-Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Surgery,Orebro Univ, Sweden(Swepub:oru)eso (författare)
  • Lindberg, FredrikDepartment of Surgical and Perioperative Sciences Surgery, Umeå University, Umeå, Sweden,Umea Univ, Sweden (författare)
  • Johnsen, GjermundDepartment of Gastrointestinal Surgery, Norwegian University of Science and Technology, Trondheim, Norway,Norwegian Univ Sci & Technol, Norway (författare)
  • Førland, Dag TidemannDepartment of Pediatric and Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway (författare)
  • Johansson, JanDepartment of Surgery, Skane University Hospital, Lund, Sweden,Skane Univ Hosp, Sweden (författare)
  • Kauppila, Joonas HDepartment of Surgery, University of Oulu and Oulu University Hospital, Oulu, Finland,Univ Oulu, Finland; Oulu Univ Hosp, Finland (författare)
  • Svendsen, Lars BoDepartment of Surgery and Transplantation, Copenhagen University Hospital, Copenhagen, Denmark,Copenhagen Univ Hosp, Denmark (författare)
  • Nilsson, MagnusKarolinska Institutet (författare)
  • Lindblad, MatsKarolinska Institutet (författare)
  • Lagergren, PernillaKarolinska Institutet (författare)
  • Larsen, Michael HareskovDepartment of Surgery, Odense University Hospital, Odense, Denmark,Odense Univ Hosp, Denmark (författare)
  • Åkesson, OscarDepartment of Surgery, Skane University Hospital, Lund, Sweden,Skane Univ Hosp, Sweden (författare)
  • Löfdahl, PerDepartment of Surgery, Sahlgrenska University Hospital, Gothenburg, Sweden,Sahlgrens Univ Hosp, Sweden (författare)
  • Mala, TomDepartment of Pediatric and Gastrointestinal Surgery, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Norway (författare)
  • Achiam, Michael PatrickDepartment of Surgery and Transplantation, Copenhagen University Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark,Copenhagen Univ Hosp, Denmark; Univ Copenhagen, Denmark (författare)
  • Karolinska InstitutetDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diseases of the esophagus: John Wiley & Sons37:61120-86941442-2050

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