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An individual participant data meta-analysis of psychological interventions for preventing depression relapse

Breedvelt, Josefien J. F. (författare)
Department of Psychiatry, Amsterdam Public Health (APH), Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands; Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK
Karyotaki, Eirini (författare)
Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; WHO Collaborating Centre for Research and Dissemination of Psychological Interventions, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Warren, Fiona C. (författare)
Department of Health and Community Sciences, University of Exeter, Exeter, UK
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Brouwer, Marlies E. (författare)
Department of Psychiatry, Amsterdam Public Health (APH), Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands
Jermann, Françoise (författare)
Department of Psychiatry, Geneva University Hospitals, Geneva, Switzerland
Holländare, Fredrik, Docent, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Psychiatry
Klein, Nicola (författare)
Trauma Center Department, GGZ Drenthe Mental Health Institute, Assen, Netherlands
de Jonge, Margo (författare)
Research Department, Arkin Mental Health Institute, Amsterdam, Netherlands
Klein, Daniel N. (författare)
Department of Psychology, Stony Brook University, Stony Brook, NY, USA
Farb, Norman (författare)
Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada; Department of Psychological Clinical Science, University of Toronto Scarborough, Toronto, Ontario, Canada
Segal, Zindel (författare)
Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada
Biesheuvel Leliefeld, Karolien E. M. (författare)
Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
Jarrett, Robin (författare)
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
Vittengl, Jeffrey (författare)
Department of Psychology, Truman State University, Kirksville, MO, USA
Thase, Michael (författare)
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
Ma, Helen (författare)
Hong Kong Centre for Mindfulness, Hong Kong, Hong Kong
Kuyken, Willem (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Shallcross, Amanda J. (författare)
Department of Population Health, NYU School of Medicine, New York, NY, USA
van Heeringen, Cornelis (författare)
Faculty of Medicine and Health Sciences, Ghent University, Gent, Belgium
Hoorelbeke, Kristof (författare)
Department of Experimental Clinical and Health Psychology, Ghent University, Gent, Belgium
Koster, Ernst (författare)
Department of Experimental Clinical and Health Psychology, Ghent University, Gent, Belgium
Williams, Mark (författare)
Department of Psychiatry, University of Oxford, Oxford, UK
Huijbers, Marloes J. (författare)
Department of Psychiatry, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands
Speckens, Anne (författare)
Department of Psychiatry, Donders Center for Medical Neuroscience, Radboud University Medical Center, Nijmegen, Netherlands
Cuijpers, Pim (författare)
Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit Amsterdam, Amsterdam, Netherlands; WHO Collaborating Centre for Research and Dissemination of Psychological Interventions, Vrije Universiteit Amsterdam, Amsterdam, Netherlands
van Oppen, Patricia (författare)
Department of Research and Innovation, GGZ InGeest Specialized Mental Health Care, Amsterdam, Netherlands; Department of Psychiatry, Amsterdam UMC, Vrije Universiteit, APH-Research Institute, Amsterdam, Netherlands
Gilbody, Simon (författare)
York Mental Health and Addictions Research Group (MHARG), University of York, York, UK
Bockting, Claudi L. (författare)
Department of Psychiatry, Amsterdam Public Health (APH), Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, Netherlands; Centre for Urban Mental Health, University of Amsterdam, Amsterdam, Netherland
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 (creator_code:org_t)
2024
2024
Engelska.
Ingår i: Nature Mental Health. - 2731-6076. ; 2:2, s. 154-163
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Major depressive disorder is a leading cause of disability worldwide; identifying effective strategies to prevent depression relapse is crucial. This individual participant data meta-analysis addresses whether and for whom psychological interventions can be recommended for relapse prevention of major depressive disorder. One- and two-stage individual patient data meta-analyses were conducted on 14 randomized controlled trials (N = 1,720). The relapse risk over 12 months was substantially lower for those who received a psychological intervention versus treatment as usual, antidepressant medication, or evaluation-only control (hazard ratio, 0.60; 95% confidence interval, 0.48–0.74). The number of previous depression episodes moderated the treatment effect, with psychological interventions demonstrating greater efficacy for patients with three or more previous episodes. Our results suggest that adding psychological interventions to current treatment to prevent depression relapse is recommended. For patients at lower risk of relapse, less-intensive approaches may be indicated.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Psykiatri (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Psychiatry (hsv//eng)

Nyckelord

Depression
relapse prevention
Psychiatry
Psykiatri

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