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  • El-Hajj, Victor GabrielDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)

The negative impact of treatment delays on the long-term neurological outcomes of spinal dural arteriovenous fistulas : a longitudinal cohort study

  • Article/chapterEnglish2024

Publisher, publication year, extent ...

  • American Association of Neurological Surgeons,2024
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-112083
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-112083URI
  • https://doi.org/10.3171/2023.12.FOCUS23703DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:238427990URI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • OBJECTIVE: Dural arteriovenous fistulas are rare vascular malformations that affect the brain and spinal cord. Spinal dural arteriovenous fistulas (sdAVFs) are the most frequently encountered vascular malformation affecting the spinal cord. The object of this study was to evaluate the impact of treatment delays on the long-term neurological outcomes of either open surgical or interventional treatment of sdAVFs.METHODS: In this retrospective, population-based cohort study, the authors examined consecutive patients with diagnosed sdAVFs at a tertiary care center between 2005 and 2020. Patients were assessed using the Aminoff-Logue disability scale (ALS) at various time points including symptom onset, primary care visit, first specialist outpatient visit, as well as both short and long-term follow-ups. The postoperative long-term ALS gait and bladder grades constituted the primary outcomes of the study.RESULTS: Among the 34 patients included in the study, the median age was 65 years, and there was a male predominance (71%). Most lesions were in the lumbar region (47%). Significant worsening in ALS gait and bladder grades was observed preoperatively, followed by postoperative improvements (p < 0.05). There was no difference in outcomes between surgical and endovascular treatments. Older age (OR 1.10, 95% CI 1.03-1.17, p = 0.007), worse preoperative ALS gait grades (OR 5.12, 95% CI 2.18-12.4, p < 0.001), and longer time from first specialist outpatient visit to first treatment (OR 1.00, 95% CI 1.00-1.01, p = 0.040) were independently associated with worse long-term gait outcomes. Only the preoperative ALS bladder score was a predictor of worse long-term bladder function (OR 92.7, 95% CI 28.0-306.7, p < 0.001).CONCLUSIONS: Both surgical and endovascular treatments for sdAVFs led to significant neurological improvements. However, treatment delays were associated with less favorable long-term outcomes. Prompt diagnosis and early intervention prior to symptom progression may enhance recovery and help to preserve neurological function.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Daller, CorneliaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria; and; Department of Neurosurgery, University Hospital St. Pölten, Karl-Landsteiner University of Health Sciences, St. Pölten, Austria (author)
  • Fletcher-Sandersjöö, AlexanderKarolinska Institutet (author)
  • Gharios, MariaDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden (author)
  • Bydon, MohamadDepartment of Neurological Surgery, Mayo Clinic, Rochester, Minnesota, USA (author)
  • Söderman, MichaelDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden (author)
  • Jabbour, PascalDepartment of Neurological Surgery, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA (author)
  • Edström, Erik,1975-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Capio Spine Center Stockholm, Löwenströmska Hospital, Stockholm, Sweden; Department of Medical Sciences, Örebro University, Örebro, Sweden(Swepub:oru)ekem (author)
  • Elmi-Terander, AdrianKarolinska Institutet (author)
  • Arnberg, FabianKarolinska Institutet (author)
  • Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, SwedenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroradiology, Karolinska University Hospital, Stockholm, Sweden; Department of Neurosurgery, University Hospital Salzburg, Paracelsus Medical University Salzburg, Austria; and; Department of Neurosurgery, University Hospital St. Pölten, Karl-Landsteiner University of Health Sciences, St. Pölten, Austria (creator_code:org_t)

Related titles

  • In:Neurosurgical Focus: American Association of Neurological Surgeons56:31092-0684

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