SwePub
Sök i LIBRIS databas

  Utökad sökning

L773:0092 8674 OR L773:1097 4172
 

Sökning: L773:0092 8674 OR L773:1097 4172 > Infant microbes and...

  • Ahrens, Angelica P.Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32603, USA (författare)

Infant microbes and metabolites point to childhood neurodevelopmental disorders

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • Cell Press,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-112922
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-112922URI
  • https://doi.org/10.1016/j.cell.2024.02.035DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • ABIS was supported by Barndiabetesfonden (Swedish Child Diabetes Foundation) ; Swedish Council for Working Life and Social Research grant/award numbers FAS2004-1775 and FAS2004-1775; Swedish Research Council grant/award numbers K2005-72X-11242-11A, K2008-69X-20826-01-4, and K2008-69X-20826-01-4; Östgöta Brandstodsbolag; Medical Research Council of Southeast Sweden (FORSS) ; JDRF Wallenberg Foundation grant/award number K98-99D-12813-01A; ALF and LFoU grants from Region Östergötland and Linköping University, Sweden; and the Joanna Cocozza Foundation. This research was funded by JDRF grant no. 1-INO-2018-637-A-N and supported by the "Inflammation in human early life: targeting impacts on life-course health" (INITIALISE) consortium funded by the Horizon Europe Program of the European Union under grant agreement 101094099. 
  • This study has followed a birth cohort for over 20 years to find factors associated with neurodevelopmental disorder (ND) diagnosis. Detailed, early-life longitudinal questionnaires captured infection and antibiotic events, stress, prenatal factors, family history, and more. Biomarkers including cord serum metabolome and lipidome, human leukocyte antigen (HLA) genotype, infant microbiota, and stool metabolome were assessed. Among the 16,440 Swedish children followed across time, 1,197 developed an ND. Significant associations emerged for future ND diagnosis in general and for specific ND subtypes, spanning intellectual disability, speech disorder, attention-deficit/hyperactivity disorder, and autism. This investigation revealed microbiome connections to future diagnosis as well as early emerging mood and gastrointestinal problems. The findings suggest links to immunodysregulation and metabolism, compounded by stress, early-life infection, and antibiotics. The convergence of infant biomarkers and risk factors in this prospective, longitudinal study on a large-scale population establishes a foundation for early-life prediction and intervention in neurodevelopment.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hyötyläinen, Tuulia,1971-Örebro universitet,Institutionen för naturvetenskap och teknik(Swepub:oru)tihn (författare)
  • Petrone, Joseph R.Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32603, USA (författare)
  • Igelström, KajsaDepartment of Biomedical and Clinical Sciences, Division of Neurobiology, Linköping University, Linköping 58185, Sweden (författare)
  • George, Christian D.Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32603, USA (författare)
  • Garrett, Timothy J.Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610, USA (författare)
  • Oresic, Matej,1967-Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku 20520, Finland; Department of Life Technologies, University of Turku, Turku 20014, Finland(Swepub:oru)moc (författare)
  • Triplett, Eric W.Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32603, USA (författare)
  • Ludvigsson, JohnnyCrown Princess Victoria Children's Hospital and Division of Pediatrics, Department of Biomedical and Clinical Sciences, Linköping University, Linköping 58185, Sweden (författare)
  • Department of Microbiology and Cell Science, College of Agricultural and Life Sciences, University of Florida, Gainesville, FL 32603, USAInstitutionen för naturvetenskap och teknik (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Cell: Cell Press187:8, s. 1853-1873.e150092-86741097-4172

Internetlänk

Hitta via bibliotek

  • Cell (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy