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Traumatic brain injury-induced autoregulatory dysfunction and spreading depression-related neurovascular uncoupling : Pathomechanisms, perspectives, and therapeutic implications

Toth, Peter (författare)
Department of Neurosurgery, University of Pecs, Pecs, Hungary; Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Szarka, Nicolett (författare)
Department of Neurosurgery, University of Pecs, Pecs, Hungary; Department of Translational Medicine, University of Pecs, Pecs, Hungary
Farkas, Eszter (författare)
Faculty of Medicine and Faculty of Science and Informatics, Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary
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Ezer, Erzebet (författare)
Department of Neurosurgery, University of Pecs, Pecs, Hungary
Czeiter, Endre (författare)
Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
Amrein, Krisztina (författare)
Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
Ungvari, Zoltan (författare)
Department of Geriatric Medicine, Reynolds Oklahoma Center on Aging, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States
Hartings, Jed A. (författare)
Department of Neurosurgery, University of Cincinnati College of Medicine, Cincinnati, Ohio, United States
Büki, Andras, 1966- (författare)
Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
Koller, Akos (författare)
Janos Szentagothai Research Centre, University of Pecs, Pecs, Hungary; Department of Neurosurgery, University of Pecs, Pecs, Hungary; Institute of Natural Sciences, University of Physical Education, Budapest, Hungary; Department of Physiology, New York Medical College, Valhalla, New York, United States
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 (creator_code:org_t)
HighWire Press, 2016
2016
Engelska.
Ingår i: American Journal of Physiology. - : HighWire Press. - 0002-9513 .- 2163-5773. ; 311:5, s. H1118-H1131
  • Forskningsöversikt (refereegranskat)
Abstract Ämnesord
Stäng  
  • Traumatic brain injury (TBI) is a major health problem worldwide. In addition to its high mortality (35-40%), survivors are left with cognitive, behavioral, and communicative disabilities. While little can be done to reverse initial primary brain damage caused by trauma, the secondary injury of cerebral tissue due to cerebro-microvascular alterations and dysregulation of cerebral blood flow (CBF) is potentially preventable. This review focuses on functional, cellular, and molecular changes of autoregulatory function of CBF (with special focus on cerebrovascular myogenic response) that occur in cerebral circulation after TBI and explores the links between autoregulatory dysfunction, impaired myogenic response, microvascular impairment, and the development of secondary brain damage. We further provide a synthesized translational view of molecular and cellular mechanisms involved in cortical spreading depolarization-related neurovascular dysfunction, which could be targeted for the prevention or amelioration of TBI-induced secondary brain damage.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Autoregulation
brain damage
cerebral blood flow
myogenic
neurovascular coupling

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