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Cerebral Microbleed...
Cerebral Microbleeds Temporarily Become Less Visible or Invisible in Acute Susceptibility Weighted Magnetic Resonance Imaging : A Rat Study
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- Tóth, Arnold (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary; Department of Radiology, Pécs Medical School, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary
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- Berente, Zoltán (författare)
- Department of Biochemistry and Medical Chemistry, Pécs Medical School, Pécs, Hungary; János Szentágothai Research Centre, University of Pécs, Pécs, Hungary; Research Group for Experimental Diagnostic Imaging, Pécs Medical School, Pécs, Hungary
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- Bogner, Péter (författare)
- Department of Radiology, Pécs Medical School, Pécs, Hungary
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- Környei, Bálint (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary
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- Balogh, Bendegúz (författare)
- Department of Radiology, Pécs Medical School, Pécs, Hungary
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- Czeiter, Endre (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary; János Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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- Amrein, Krisztina (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary; János Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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- Dóczi, Tamás (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary; Diagnostic Center of Pécs, Pécs, Hungary
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary; János Szentágothai Research Centre, University of Pécs, Pécs, Hungary
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- Schwarcz, Attila (författare)
- Department of Neurosurgery, Pécs Medical School, Pécs, Hungary
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(creator_code:org_t)
- Mary Ann Liebert, 2019
- 2019
- Engelska.
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Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 36:10, s. 1670-1677
- Relaterad länk:
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https://doi.org/10.1...
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https://www.liebertp...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Previously, we reported human traumatic brain injury cases demonstrating acute to subacute microbleed appearance changes in susceptibility-weighted imaging (SWI-magnetic resonance imaging [MRI]). This study aims to confirm and characterize such temporal microbleed appearance alterations in an experimental model. To elicit microbleed formation, brains of male Sprague Dawley rats were pierced in a depth of 4 mm, in a parasagittal position bilaterally using 159 mu m and 474 mu m needles, without the injection of autologous blood or any agent. Rats underwent 4.7 T MRI immediately, then at multiple time points until 125 h. Volumes of hypointensities consistent with microbleeds in SWI were measured using an intensity threshold-based approach. Microbleed volumes across time points were compared using repeated measures analysis of variance. Microbleeds were assessed by Prussian blue histology at different time points. Hypointensity volumes referring to microbleeds were significantly decreased (corrected p < 0.05) at 24 h compared with the immediate or the 125 h time points. By visual inspection, microbleeds were similarly detectable at the immediate and 125 h imaging but were decreased in extent or completely absent at 24 h or 48 h. Histology confirmed the presence of microbleeds at all time points and in all animals. This study confirmed a general temporary reduction in visibility of microbleeds in the acute phase in SWI. Such short-term appearance dynamics of microbleeds should be considered when using SWI as a diagnostic tool for microbleeds in traumatic brain injury and various diseases.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- MRI
- brain trauma
- microbleed
- rat
- susceptibility weighted imaging (SWI)
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Tóth, Arnold
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Berente, Zoltán
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Bogner, Péter
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Környei, Bálint
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Balogh, Bendegúz
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Czeiter, Endre
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Amrein, Krisztin ...
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Dóczi, Tamás
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Büki, Andras, 19 ...
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Schwarcz, Attila
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Journal of Neuro ...
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Örebro universitet