Effects of pituitary adenylate cyclase activating polypeptide in a rat model of traumatic brain injury

Farkas, OrsolyaDepartment of Neurosurgery, University of Pécs, Medical Faculty, Pécs, Hungary (författare)

This work was supported by the National Science Research Fund (OTKA T034491/046589, T035195, ETT), Fogarty IRCA (1-RO3-TW0131302A1), NIH Grant NS20193, National Science Projects NFKP1A/00026/2002 and ALK 000126/2002, the Hungarian Academy of Sciences, Bolyai and Bekesy Scholarships.
Pituitary adenylate cyclase activating polypeptide (PACAP) is a widely distributed neuropeptide that has numerous different actions. Recent studies have shown that PACAP exerts neuroprotective effects not only in vitro but also in vivo, in animal models of global and focal cerebral ischemia, Parkinson's disease and axonal injuries. Traumatic brain injury has an increasing mortality and morbidity and it evokes diffuse axonal injury which further contributes to its damaging effects. The aim of the present study was to examine the possible neuroprotective effect of PACAP in a rat model of diffuse axonal injury induced by impact acceleration. Axonal damage was assessed by immunohistochemistry using an antiserum against beta-amyloid precursor protein, a marker of altered axoplasmic transport considered as key feature in axonal injury. In these experiments, we have established the dose response curves for PACAP administration in traumatic axonal injury, demonstrating that a single post-injury intracerebroventricular injection of 100 microg PACAP significantly reduced the density of damaged, beta-amyloid precursor protein-immunoreactive axons in the corticospinal tract.

Tamás, AndreaDepartment of Anatomy, University of Pécs, Medical Faculty, Pécs, Hungary (författare)
Zsombok, AndreaDepartment of Neurosurgery, University of Pécs, Medical Faculty, Pécs, Hungary; Dept. of Ctrl. Lab. of Anim. Res., University of Pécs, Medical Faculty, Hungary (författare)
Reglődi, DóraDepartment of Anatomy, University of Pécs, Medical Faculty, Pécs, Hungary (författare)
Pál, JózsefDepartment of Neurosurgery, University of Pécs, Medical Faculty, Pécs, Hungary (författare)
Büki, Andras,1966-Department of Neurosurgery, University of Pécs, Medical Faculty, Pécs, Hungary(Swepub:oru)asbi (författare)
Lengvári, IstvánDepartment of Anatomy, University of Pécs, Medical Faculty, Pécs, Hungary (författare)
Povlishock, John T.Dept. of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, VA, United States (författare)
Dóczi, TamásDepartment of Neurosurgery, University of Pécs, Medical Faculty, Pécs, Hungary (författare)
Department of Neurosurgery, University of Pécs, Medical Faculty, Pécs, HungaryDepartment of Anatomy, University of Pécs, Medical Faculty, Pécs, Hungary (creator_code:org_t)

Av författaren/redakt...: Farkas, Orsolya; Tamás, Andrea; Zsombok, Andrea; Reglődi, Dóra; Pál, József; Büki, Andras, 19 ...; visa fler...; Lengvári, István; Povlishock, John ...; Dóczi, Tamás; visa färre...

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