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αII-spectrin breakdown products (SBDPs) : diagnosis and outcome in severe traumatic brain injury patients

Mondello, Stefania (författare)
Department of Clinical Programs and Center of Innovative Research, and Department of Anesthesiology, University of Florida, Gainesville, Florida, United States
Robicsek, Steven A. (författare)
Department of Anesthesiology, University of Florida, Gainesville, Florida, United States
Gabrielli, Andrea (författare)
Department of Anesthesiology, University of Florida, Gainesville, Florida, United States
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Brophy, Gretchen M. (författare)
Department of Pharmacy and Neurosurgery, Virginia Commonwealth Universitya, Richmond, Virginia, United States
Papa, Linda (författare)
Department of Emergency Medicine, Orlando Regional Medical Center, Orlando, Florida, United States
Tepas, Joseph (författare)
Department of Surgery and Pediatrics, University of Florida, Jacksonville, Florida, United States
Robertson, Claudia (författare)
Department of Critical Care, Baylor College of Medicine, Houston, Texas, United States
Büki, Andras, 1966- (författare)
Department of Neurosurgery, University of Pécs, Pécs, Hungary
Scharf, Dancia (författare)
Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
Jixiang, Mo (författare)
Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
Akinyi, Linnet (författare)
Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
Muller, Uwe (författare)
Department of Research and Development, Banyan Biomarkers Inc., Alachua, Florida, United States
Wang, Kevin K.W. (författare)
Center of Innovative Research, Banyan Biomarkers Inc., and University of Florida, Department of Psychiatry, Gainesville, Florida, United States
Hayes, Ronald L. (författare)
Department of Clinical Programs, Banyan Biomarkers Inc., and University of Florida, Department of Anesthesiology, Gainesville, Florida, United States
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 (creator_code:org_t)
Mary Ann Liebert, 2010
2010
Engelska.
Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 27:7, s. 1203-1213
Relaterad länk:
https://europepmc.or...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • In this study we assessed the clinical utility of quantitative assessments of alphaII-spectrin breakdown products (SBDP145 produced by calpain, and SBDP120 produced by caspase-3) in cerebrospinal fluid (CSF) as markers of brain damage and outcome after severe traumatic brain injury (TBI). We analyzed 40 adult patients with severe TBI (Glasgow Coma Scale [GCS] score 6 ng/mL) and SBDP120 levels (>17.55 ng/mL) strongly predicted death (odds ratio 5.9 for SBDP145, and 18.34 for SBDP120). The time course of SBDPs in nonsurvivors also differed from that of survivors. These results suggest that CSF SBDP levels can predict injury severity and mortality after severe TBI, and can be useful complements to clinical assessment. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

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