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  • Brophy, Gretchen M.Virginia Commonwealth University, Pharmacotherapy & Outcomes Sciences and Neurosurgery, Richmond, Virginia, United States (author)

Biokinetic analysis of ubiquitin C-terminal hydrolase-L1 (UCH-L1) in severe traumatic brain injury patient biofluids

  • Article/chapterEnglish2011

Publisher, publication year, extent ...

  • Mary Ann Liebert,2011
  • printrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:oru-113426
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113426URI
  • https://doi.org/10.1089/neu.2010.1564DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • This study was supported in part by Department of Defense Award number DoD W81XWH-06-1-0517, and National Institutes of Health Award number R01 NS052831.
  • Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a neuron-specific enzyme that has been identified as a potential biomarker of traumatic brain injury (TBI). The study objectives were to determine UCH-L1 exposure and kinetic metrics, determine correlations between biofluids, and assess outcome correlations in severe TBI patients. Data were analyzed from a prospective, multicenter study of severe TBI (Glasgow Coma Scale [GCS] score ≤ 8). Cerebrospinal fluid (CSF) and serum data from samples taken every 6 h after injury were analyzed by enzyme-linked immunosorbent assay (ELISA). UCH-L1 CSF and serum data from 59 patients were used to determine biofluid correlations. Serum samples from 86 patients and CSF from 59 patients were used to determine outcome correlations. Exposure and kinetic metrics were evaluated acutely and up to 7 days post-injury and compared to mortality at 3 months. There were significant correlations between UCH-L1 CSF and serum median concentrations (r(s)=0.59, p<0.001), AUC (r(s)=0.3, p=0.027), Tmax (r(s)=0.68, p<0.001), and MRT (r(s)=0.65, p<0.001). Outcome analysis showed significant increases in median serum AUC (2016 versus 265 ng/mL*min, p=0.006), and Cmax (2 versus 0.4 ng/mL, p=0.003), and a shorter Tmax (8 versus 19 h, p=0.04) in those who died versus those who survived, respectively. In the first 24 h after injury, there was a statistically significant acute increase in CSF and serum median Cmax((0-24h)) in those who died. This study shows a significant correlation between UCH-L1 CSF and serum median concentrations and biokinetics in severe TBI patients, and relationships with clinical outcome were detected. 

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Mondello, StefaniaDepartment of Clinical Programs and Center of Innovative Research, and Department of Anesthesiology, University of Florida, Gainesville, Florida, Unites States (author)
  • Papa, LindaEmergency Medicine, Orlando Regional Medical Center, Orlando, Florida, United States (author)
  • Robicsek, Steven A.Department of Anesthesiology, University of Florida, Gainesville, Florida, United States (author)
  • Gabrielli, AndreaDepartment of Anesthesiology, University of Florida, Gainesville, Florida, United States (author)
  • Tepas, JosephDepartment of Surgery and Pediatrics, University of Florida, Jacksonville, Florida, United States (author)
  • Büki, Andras,1966-Department of Neurosurgery, University of Pécs, Pécs, Hungary(Swepub:oru)asbi (author)
  • Robertson, ClaudiaDepartment of Critical Care, Baylor College of Medicine, Houston, Texas, United States (author)
  • Tortella, Frank C.Walter Reed Army Institute of Research, Silver Spring, Maryland, United States (author)
  • Hayes, Ronald L.Department of Clinical Programs, Banyan Biomarkers Inc., and Department of Anesthesiology, University of Florida, Gainesville, Florida, United States (author)
  • Wang, Kevin K.W.Center of Innovative Research, Banyan Biomarkers Inc., and Department of Psychiatry, University of Florida, Gainesville, Florida, United States (author)
  • Virginia Commonwealth University, Pharmacotherapy &amp; Outcomes Sciences and Neurosurgery, Richmond, Virginia, United StatesDepartment of Clinical Programs and Center of Innovative Research, and Department of Anesthesiology, University of Florida, Gainesville, Florida, Unites States (creator_code:org_t)

Related titles

  • In:Journal of Neurotrauma: Mary Ann Liebert28:6, s. 861-8700897-71511557-9042

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