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Sökning: id:"swepub:oai:DiVA.org:oru-113600" > Ability of serum gl...

  • Welch, Robert D.Department of Emergency Medicine, Wayne State University, Detroit, Michigan, United States (författare)

Ability of serum glial fibrillary Acidic Protein, Ubiquitin C-Terminal Hydrolase-L1, and S100B to differentiate normal and abnormal head computed tomography findings in patients with suspected mild or moderate traumatic brain injury

  • Artikel/kapitelEngelska2016

Förlag, utgivningsår, omfång ...

  • Mary Ann Liebert,2016
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-113600
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113600URI
  • https://doi.org/10.1089/neu.2015.4149DOI
  • https://lup.lub.lu.se/record/8152299URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agency:United States Department of DefenseUnited States ArmyU.S. Army Medical Research & Materiel Command (USAMRMC)
  • Head computed tomography (CT) imaging is still a commonly obtained diagnostic test for patients with minor head injury despite availability of clinical decision rules to guide imaging use and recommendations to reduce radiation exposure resulting from unnecessary imaging. This prospective multicenter observational study of 251 patients with suspected mild to moderate traumatic brain injury (TBI) evaluated three serum biomarkers' (glial fibrillary acidic protein [GFAP], ubiquitin C-terminal hydrolase-L1 [UCH-L1] and S100B measured within 6 h of injury) ability to differentiate CT negative and CT positive findings. Of the 251 patients, 60.2% were male and 225 (89.6%) had a presenting Glasgow Coma Scale score of 15. A positive head CT (intracranial injury) was found in 36 (14.3%). UCH-L1 was 100% sensitive and 39% specific at a cutoff value >40 pg/mL. To retain 100% sensitivity, GFAP was 0% specific (cutoff value 0 pg/mL) and S100B had a specificity of only 2% (cutoff value 30 pg/mL). All three biomarkers had similar values for areas under the receiver operator characteristic curve: 0.79 (95% confidence interval; 0.70-0.88) for GFAP, 0.80 (0.71-0.89) for UCH-L1, and 0.75 (0.65-0.85) for S100B. Neither GFAP nor UCH-L1 curve values differed significantly from S100B (p = 0.21 and p = 0.77, respectively). In our patient cohort, UCH-L1 outperformed GFAP and S100B when the goal was to reduce CT use without sacrificing sensitivity. UCH-L1 values <40 pg/mL could potentially have aided in eliminating 83 of the 215 negative CT scans. These results require replication in other studies before the test is used in actual clinical practice. 

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Ayaz, Syed I.Department of Emergency Medicine, Wayne State University, Detroit, Michigan, United States (författare)
  • Lewis, Lawrence M.Department of Emergency Medicine, Washington University, St. Louis, Missouri, Unites States (författare)
  • Undén, JohanLund University,Lunds universitet,Anestesiologi och intensivvård,Forskargrupper vid Lunds universitet,Anaesthesiology and Intensive Care Medicine,Lund University Research Groups,Department of Anesthesiology and Intensive Care, Clinical Sciences in Malmo, Malmo, Sweden(Swepub:lu)neur-jun (författare)
  • Chen, James Y.Department of Radiology, University of California, San Diego Health System, San Diego, California, United States (författare)
  • Mika, Valerie H.Department of Emergency Medicine, Wayne State University, Detroit, Michigan, United States (författare)
  • Saville, BenBerry Consultants, Austin, Texas, United States (författare)
  • Tyndall, Joseph A.Department of Emergency Medicine, University of Florida, Gainesville, Florida, United States (författare)
  • Nash, MarshallNeurostudies.net, Decatur, Georgia, United States (författare)
  • Büki, Andras,1966-Department of Neurosurgery, Pecs University, Pecs, Hungary(Swepub:oru)asbi (författare)
  • Barzo, PalDepartment of Neurosurgery, University of Szeged, Szeged, Hungary (författare)
  • Hack, DallasU.S. Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States (författare)
  • Tortella, Frank C.Applied Neurobiology, Silver Spring, Maryland, United States (författare)
  • Schmid, KaraCenter for Military Psychiatry and Neuroscience Walter Reed Army Institute of Research, Silver Spring, Maryland, United States (författare)
  • Hayes, Ronald L.Center of Innovative Research, Banyan Biomarkers, Inc., Alachua, Florida, United States (författare)
  • Vossough, ArastooDepartment of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, United States (författare)
  • Sweriduk, Stephen T.Department of Radiology, Shields Health Care Group, Brockton, Massachusetts, United States (författare)
  • Bazarian, Jeffrey J.Department of Emergency Medicine, University of Rochester School of Medicine, Rochester, New York, United States (författare)
  • Department of Emergency Medicine, Wayne State University, Detroit, Michigan, United StatesDepartment of Emergency Medicine, Washington University, St. Louis, Missouri, Unites States (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Journal of Neurotrauma: Mary Ann Liebert33:2, s. 203-2140897-71511557-9042

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