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  • Juhász, AnnamáriaUniversity of Pécs, Pécs, Hungary (författare)

How efficient is subthalamic deep brain stimulation in reducing dyskinesia in parkinson's disease?

  • Artikel/kapitelEngelska2017

Förlag, utgivningsår, omfång ...

  • 2017-04-08
  • S. Karger,2017
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-113602
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-113602URI
  • https://doi.org/10.1159/000455208DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Funding Agencies:Hungarian Academy of SciencesHungarian Brain Research ProgramMinistry of Human Capacities, Hungary
  • Background: Dyskinesia is among the most troublesome symptoms of advanced Parkinson's disease (PD). The recently developed Unified Dyskinesia Rating Scale (UDysRS) can simultaneously measure several subjective and objective aspects of dyskinesia, irrespective of the other motor symptoms of PD. Despite the advantages of deep brain stimulation (DBS), previous studies on DBS have not used the UDysRS yet.Methods: In this prospective study, 71 consecutive patients undergoing DBS implantation were enrolled. Patients were examined twice: 1 week prior to the DBS implantation (baseline) and 12 months postoperatively. The severity of PD-related symptoms was assessed by the Movement Disorders Society Unified PD Rating Scale (MDS-UPDRS). The presence and severity of dyskinesia were specifically measured by the UDysRS and patient diaries.Results: At baseline, all 71 patients had dyskinesia, but 1 year after DBS implantation, 25 patients were dyskinesia-free, and an additional 19 had only mild dyskinesia. The total score on the UDysRS decreased from 38.0 ± 17.8 to 10.8 ± 13.0 (p < 0.001). Besides this, all parts of the UDysRS showed significant improvement after STN DBS treatment, and the magnitude of these changes had a large effect size. The total score of MDS-UPDRS improved from 76.5 ± 24.3 to 60.4 ± 21.4 points (p < 0.001).Conclusions: Based on our results, UDysRS can reliably detect improvements in dyskinesia after DBS implantation.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Deli, GabriellaUniversity of Pécs, Pécs, Hungary (författare)
  • Aschermann, ZsuzsannaUniversity of Pécs, Pécs, Hungary (författare)
  • Janszky, JózsefUniversity of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary (författare)
  • Harmat, MárkUniversity of Pécs, Pécs, Hungary (författare)
  • Makkos, AttilaUniversity of Pécs, Pécs, Hungary (författare)
  • Kovács, MártonUniversity of Pécs, Pécs, Hungary (författare)
  • Komoly, SámuelUniversity of Pécs, Pécs, Hungary (författare)
  • Balás, IstvánUniversity of Pécs, Pécs, Hungary (författare)
  • Dóczi, TamásUniversity of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary (författare)
  • Büki, Andras,1966-University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary(Swepub:oru)asbi (författare)
  • Kovács, NorbertUniversity of Pécs, Pécs, Hungary (författare)
  • University of Pécs, Pécs, HungaryUniversity of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:European Neurology: S. Karger77:5-6, s. 281-2870014-30221421-9913

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