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Pre-clinical testin...
Pre-clinical testing of therapies for traumatic brain injury
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- DeWitt, Douglas S. (author)
- Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States
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- Hawkins, Bridget E. (author)
- Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States
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- Dixon, C. Edward (author)
- Department of Neurological Surgery, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
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- Kochanek, Patrick M. (author)
- Department of Critical Care Medicine, Safar Center for Resuscitation Research, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States
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- Armstead, William (author)
- Department of Anesthesiology and Critical Care, University of Pennsylvania, Philadelphia, Pennsylvania, United States
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- Bass, Cameron R. (author)
- Department of Biomedical Engineering, Duke University, Durham, North Carolina, United States
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- Bramlett, Helen M. (author)
- Department of Neurological Surgery, The Miami Project to Cure Paralysis, Miami, Florida, United States
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- Büki, Andras, 1966- (author)
- Department of Neurosurgery, Medical University of Pécs, Pécs, Hungary
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- Dietrich, W. Dalton (author)
- The Miami Project to Cure Paralysis, Leonard M. Miller School of Medicine, University of Miami, Miami, Florida, United States
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- Ferguson, Adam R. (author)
- Weill Institute for Neurosciences, Brain and Spinal Injury Center (BASIC), Department of Neurological Surgery, University of California, San Francisco (UCSF), San Francisco, California, United States
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- Hall, Edward D. (author)
- Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky Medical Center, Lexington, Kentucky, United States
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- Hayes, Ronald L. (author)
- University of Florida, Virginia Commonwealth University, Banyan Biomarkers, Inc., Alachua, Florida, United States
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- Hinds, Sidney R. (author)
- United States Army Medical Research and Materiel Command, Fort Detrick, Maryland, United States
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- LaPlaca, Michelle C. (author)
- Georgia Institute of Technology/Emory University, Atlanta, Georgia, United States
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- Long, Joseph B. (author)
- Blast-Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States
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- Meaney, David F. (author)
- Department of Bioengineering, University of Pennsylvania, Philadelphia, Pennsylvania, United States
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- Mondello, Stefania (author)
- Department of Neurosciences, University of Messina, Via Consolare Valeria, Messina, Italy
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- Noble-Haeusslein, Linda J. (author)
- Departments of Neurology and Psychology, Dell Medical School, The University of Texas at Austin, Austin, Texas, United States
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- Poloyac, Samuel M. (author)
- Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, Pennsylvania, United States
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- Prough, Donald S. (author)
- Department of Anesthesiology, University of Texas Medical Branch, Galveston, Texas, United States
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- Robertson, Claudia S. (author)
- Department of Neurosurgery, Baylor College of Medicine, Houston, Texas, United States
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- Saatman, Kathryn E. (author)
- Spinal Cord and Brain Injury Research Center (SCoBIRC), University of Kentucky, Lexington, Kentucky, United States
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- Shultz, Sandy R. (author)
- Department of Medicine, Melbourne Brain Center, The University of Melbourne, Parkville, Victoria, Australia
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- Shear, Deborah A. (author)
- Brain Trauma Neuroprotection Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States
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- Smith, Douglas H. (author)
- Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, United States
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- Valadka, Alex B. (author)
- Department of Neurosurgery, Virginia Commonwealth University School of Medicine, Richmond, Virginia, United States
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- VandeVord, Pamela (author)
- Department of Biomedical Engineering and Mechanics, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States
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- Zhang, Liying (author)
- Department of Biomedical Engineering, Wayne State University, Detroit, Michigan, United States
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(creator_code:org_t)
- Mary Ann Liebert, 2018
- 2018
- English.
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In: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 35:23, s. 2737-2754
- Related links:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Despite the large number of promising neuroprotective agents identified in experimental traumatic brain injury (TBI) studies, none has yet shown meaningful improvements in long-term outcome in clinical trials. To develop recommendations and guidelines for pre-clinical testing of pharmacological or biological therapies for TBI, the Moody Project for Translational Traumatic Brain Injury Research hosted a symposium attended by investigators with extensive experience in pre-clinical TBI testing. The symposium participants discussed issues related to pre-clinical TBI testing including experimental models, therapy and outcome selection, study design, data analysis, and dissemination. Consensus recommendations included the creation of a manual of standard operating procedures with sufficiently detailed descriptions of modeling and outcome measurement procedures to permit replication. The importance of the selection of clinically relevant outcome variables, especially related to behavior testing, was noted. Considering the heterogeneous nature of human TBI, evidence of therapeutic efficacy in multiple, diverse (e.g., diffuse vs. focused) rodent models and a species with a gyrencephalic brain prior to clinical testing was encouraged. Basing drug doses, times, and routes of administration on pharmacokinetic and pharmacodynamic data in the test species was recommended. Symposium participants agreed that the publication of negative results would reduce costly and unnecessary duplication of unsuccessful experiments. Although some of the recommendations are more relevant to multi-center, multi-investigator collaborations, most are applicable to pre-clinical therapy testing in general. The goal of these consensus guidelines is to increase the likelihood that therapies that improve outcomes in pre-clinical studies will also improve outcomes in TBI patients.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Guidelines
- pre-clinical
- traumatic brain injury
Publication and Content Type
- ref (subject category)
- art (subject category)
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DeWitt, Douglas ...
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Hawkins, Bridget ...
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Dixon, C. Edward
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Kochanek, Patric ...
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Armstead, Willia ...
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Bass, Cameron R.
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show more...
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Bramlett, Helen ...
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Büki, Andras, 19 ...
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Dietrich, W. Dal ...
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Ferguson, Adam R ...
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Hall, Edward D.
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Hayes, Ronald L.
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Hinds, Sidney R.
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LaPlaca, Michell ...
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Long, Joseph B.
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Meaney, David F.
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Mondello, Stefan ...
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Noble-Haeusslein ...
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Poloyac, Samuel ...
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Prough, Donald S ...
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Robertson, Claud ...
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Saatman, Kathryn ...
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Shultz, Sandy R.
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Shear, Deborah A ...
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Smith, Douglas H ...
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Valadka, Alex B.
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VandeVord, Pamel ...
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Zhang, Liying
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Journal of Neuro ...
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Örebro University