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Single mild traumat...
Single mild traumatic brain injury induces persistent disruption of the blood-brain barrier, neuroinflammation and ognitive decline in hypertensive rats
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- Szarka, Nikolett (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary; Clinical Medicine Doctoral School, University of Szeged, Szeged, Hungary
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- Toth, Luca (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary
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- Czigler, Andras (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary
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- Kellermayer, Zoltan (författare)
- Department of Immunology and Biotechnology, University of Pecs, Medical School, Pecs, Hungary
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- Ungvari, Zoltan (författare)
- Reynolds Oklahoma Center on Aging, Donald W. Reynolds Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA
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- Amrein, Krisztina (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary
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- Czeiter, Endre (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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- Bali, Zsolt Kristof (författare)
- Translational Neuroscience Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary; Grastyan Translational Research Center, University of Pecs, Pecs, Hungary
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- Tadepalli, Sai Ambika (författare)
- Translational Neuroscience Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary
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- Wahr, Matyas (författare)
- Cellular Neurobiology, Institute of Physiology, Medical School, University of Pecs, Pecs, Hungary
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- Hernadi, Istvan (författare)
- Translational Neuroscience Research Group, Szentagothai Research Center, University of Pecs, Pecs, Hungary; Grastyan Translational Research Center, University of Pecs, Pecs, Hungary; Department of Experimental Neurobiology, Faculty of Sciences, University of Pecs, Pecs, Hungary
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- Koller, Akos (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary; Department of Morphology and Physiology, Faculty of Health Sciences, Semmelweis University, Budapest, Hungary; Department of Physiology, New York Medical College, Valhalla, New York, USA
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary
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- Toth, Peter (författare)
- Department of Neurosurgery and Szentagothai Research Center, University of Pecs, Medical School, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary; Clinical Medicine Doctoral School, University of Szeged, Szeged, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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(creator_code:org_t)
- 2019-06-30
- 2019
- Engelska.
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Ingår i: International Journal of Molecular Sciences. - : MDPI. - 1661-6596 .- 1422-0067. ; 20:13, s. 3223-3223
- Relaterad länk:
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https://doi.org/10.3...
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Traumatic brain injury (TBI) induces blood-brain barrier (BBB) disruption, which contributes to secondary injury of brain tissue and development of chronic cognitive decline. However, single mild (m)TBI, the most frequent form of brain trauma disrupts the BBB only transiently. We hypothesized, that co-morbid conditions exacerbate persistent BBB disruption after mTBI leading to long term cognitive dysfunction. Since hypertension is the most important cerebrovascular risk factor in populations prone to mild brain trauma, we induced mTBI in normotensive Wistar and spontaneously hypertensive rats (SHR) and we assessed BBB permeability, extravasation of blood-borne substances, neuroinflammation and cognitive function two weeks after trauma. We found that mTBI induced a significant BBB disruption two weeks after trauma in SHRs but not in normotensive Wistar rats, which was associated with a significant accumulation of fibrin and increased neuronal expression of inflammatory cytokines TNFα, IL-1β and IL-6 in the cortex and hippocampus. SHRs showed impaired learning and memory two weeks after mild TBI, whereas cognitive function of normotensive Wistar rats remained intact. Future studies should establish the mechanisms through which hypertension and mild TBI interact to promote persistent BBB disruption, neuroinflammation and cognitive decline to provide neuroprotection and improve cognitive function in patients with mTBI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- BBB
- cognitive dysfunction
- hypertension
- mild brain trauma
- vascular injury
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- ref (ämneskategori)
- art (ämneskategori)
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Szarka, Nikolett
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Toth, Luca
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Czigler, Andras
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Kellermayer, Zol ...
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Ungvari, Zoltan
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Amrein, Krisztin ...
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visa fler...
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Czeiter, Endre
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Bali, Zsolt Kris ...
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Tadepalli, Sai A ...
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Wahr, Matyas
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Hernadi, Istvan
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Koller, Akos
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Büki, Andras, 19 ...
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Toth, Peter
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- MEDICIN OCH HÄLSOVETENSKAP
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och Klinisk medicin
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och Neurologi
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Örebro universitet