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Blood-based protein...
Blood-based protein biomarkers for the management of traumatic brain injuries in adults presenting to emergency departments with mild brain injury : A living systematic review and meta-analysis
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- Mondello, Stefania (författare)
- Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy
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- Sorinola, Abayomi (författare)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary
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- Czeiter, Endre (författare)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary; János Szentágothai Research Centre, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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- Vámos, Zoltán (författare)
- Anesthesiology and Intensive Therapy, University of Pecs, Pecs, Hungary
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- Amrein, Krisztina (författare)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary; János Szentágothai Research Centre, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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- Synnot, Anneliese (författare)
- Australian & New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Victoria, Australia; Cochrane Consumers and Communication Group, Centre for Health Communication and Participation, La Trobe University, Melbourne, Victoria, Australia
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- Donoghue, Emma (författare)
- Australian & New Zealand Intensive Care Research Centre (ANZIC-RC), Monash University, Melbourne, Victoria, Australia; Cochrane Consumers and Communication Group, Centre for Health Communication and Participation, La Trobe University, Melbourne, Victoria, Australia
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- Sándor, János (författare)
- Department of Preventive Medicine, Division of Biostatistics and Epidemiology, University of Debrecen, Debrecen, Hungary
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- Wang, Kevin K.W. (författare)
- Program for Neuroproteomics & Biomarkers Research, Departments of Psychiatry & Neuroscience, McKnight Brain Institute, University of Florida, Gainesville, Florida, USA
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- Diaz-Arrastia, Ramon (författare)
- Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA
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- Steyerberg, Ewout W. (författare)
- Center for Clinical Decision Sciences, Department of Public Health, Erasmus Medical Center, Rotterdam, The Netherlands
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- Menon, David K. (författare)
- Division of Anaesthesia, University of Cambridge, Cambridge, United Kingdom
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- Maas, Andrew I.R. (författare)
- Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Antwerp, Belgium
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, University of Pecs, Pecs, Hungary; János Szentágothai Research Centre, University of Pecs, Pecs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pecs, Hungary
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(creator_code:org_t)
- Mary Ann Liebert, 2021
- 2021
- Engelska.
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Ingår i: Journal of Neurotrauma. - : Mary Ann Liebert. - 0897-7151 .- 1557-9042. ; 38:8, s. 1086-1106
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100 calcium binding protein B [S100B], glial fibrillary acidic protein [GFAP], neuron specific enolase [NSE], ubiquitin C-terminal hydrolase-L1 [UCH-L1]. tau, and neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI. Effects of potential confounding factors and differential diagnostic performance of the included markers were explored. Further, appropriateness of study design, analysis, quality, and demonstration of clinical utility were assessed. Studies published up to October 2016 were identified through searches of MEDLINE®, Embase, EBM Reviews, the Cochrane Library, World Health Organization (WHO), International Clinical Trials Registry Platform (ICTRP), and clinicaltrials.gov. Following screening of the identified articles, 26 were selected as relevant. We found that measurement of S100B can help informed decision making in the emergency department, possibly reducing resource use; however, there is insufficient evidence that any of the other markers is ready for clinical application. Our work pointed out serious problems in the design, analysis, and reporting of many of the studies, and identified substantial heterogeneity and research gaps. These findings emphasize the importance of methodologically rigorous studies focused on a biomarker's intended use, and defining standardized, validated, and reproducible approaches. The living nature of this systematic review, which will summarize key updated information as it becomes available, can inform and guide future implementation of biomarkers in the clinical arena.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- TBI
- biomarkers
- diagnosis
- living systematic review
- meta-analysis
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Mondello, Stefan ...
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Sorinola, Abayom ...
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Czeiter, Endre
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Vámos, Zoltán
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Amrein, Krisztin ...
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Synnot, Annelies ...
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visa fler...
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Donoghue, Emma
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Sándor, János
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Wang, Kevin K.W.
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Diaz-Arrastia, R ...
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Steyerberg, Ewou ...
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Menon, David K.
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Maas, Andrew I.R ...
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Büki, Andras, 19 ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Neurologi
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Journal of Neuro ...
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Örebro universitet