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Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults

Toth, Luca (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary
Czigler, Andras (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary
Hegedus, Emoke (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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Komaromy, Hedvig (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
Amrein, Krisztina (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
Czeiter, Endre (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
Yabluchanskiy, Andriy (författare)
Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
Koller, Akos (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
Orsi, Gergely (författare)
ELKH-PTE Clinical Neuroscience MR Research Group, Eötvös Lóránd Research Network (ELKH), Pecs, Hungary; Department of Neurology, Medical School, University of Pecs, Pecs, Hungary
Perlaki, Gabor (författare)
ELKH-PTE Clinical Neuroscience MR Research Group, Eötvös Lóránd Research Network (ELKH), Pecs, Hungary; Department of Neurology, Medical School, University of Pecs, Pecs, Hungary
Schwarcz, Attila (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
Büki, Andras, 1966- (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
Ungvari, Zoltan (författare)
Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary
Toth, Peter J. (författare)
Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary; Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary
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 (creator_code:org_t)
2022-07-23
2022
Engelska.
Ingår i: GeroScience. - : Springer. - 2509-2715 .- 2509-2723. ; 44:6, s. 2771-2783
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young (n = 31, 11 female, 20 male, mean age: 28.4 + / - 4.2 years) and aged volunteers (n = 32, 18 female, 14 male, mean age: 67.9 + / - 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults. 

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Aging
cognitive decline
neurovascular uncoupling
VCI
VCID
vascular cognitive impairment

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