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Age-related decline...
Age-related decline in circulating IGF-1 associates with impaired neurovascular coupling responses in older adults
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- Toth, Luca (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary
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- Czigler, Andras (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary
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- Hegedus, Emoke (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Komaromy, Hedvig (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Amrein, Krisztina (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Czeiter, Endre (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Yabluchanskiy, Andriy (författare)
- Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA
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- Koller, Akos (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Orsi, Gergely (författare)
- ELKH-PTE Clinical Neuroscience MR Research Group, Eötvös Lóránd Research Network (ELKH), Pecs, Hungary; Department of Neurology, Medical School, University of Pecs, Pecs, Hungary
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- Perlaki, Gabor (författare)
- ELKH-PTE Clinical Neuroscience MR Research Group, Eötvös Lóránd Research Network (ELKH), Pecs, Hungary; Department of Neurology, Medical School, University of Pecs, Pecs, Hungary
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- Schwarcz, Attila (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Büki, Andras, 1966- (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary
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- Ungvari, Zoltan (författare)
- Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA; Department of Health Promotion Sciences, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, USA; The Peggy and Charles Stephenson Cancer Center, University of Oklahoma Health Sciences Center, Oklahoma City, USA; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary
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- Toth, Peter J. (författare)
- Department of Neurosurgery, Medical School, University of Pecs, Pecs, Hungary; Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary; Vascular Cognitive Impairment and Neurodegeneration Program, Oklahoma Center for Geroscience and Healthy Brain Aging, Department of Biochemistry and Molecular Biology, University of Oklahoma Health Sciences Center, Oklahoma City, USA; International Training Program in Geroscience, Doctoral School of Basic and Translational Medicine/Department of Public Health, Semmelweis University, Budapest, Hungary
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(creator_code:org_t)
- 2022-07-23
- 2022
- Engelska.
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Ingår i: GeroScience. - : Springer. - 2509-2715 .- 2509-2723. ; 44:6, s. 2771-2783
- Relaterad länk:
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Impairment of moment-to-moment adjustment of cerebral blood flow (CBF) to the increased oxygen and energy requirements of active brain regions via neurovascular coupling (NVC) contributes to the genesis of age-related cognitive impairment. Aging is associated with marked deficiency in the vasoprotective hormone insulin-like growth factor-1 (IGF-1). Preclinical studies on animal models of aging suggest that circulating IGF-1 deficiency is causally linked to impairment of NVC responses. The present study was designed to test the hypotheses that decreases in circulating IGF-1 levels in older adults also predict the magnitude of age-related decline of NVC responses. In a single-center cross-sectional study, we enrolled healthy young (n = 31, 11 female, 20 male, mean age: 28.4 + / - 4.2 years) and aged volunteers (n = 32, 18 female, 14 male, mean age: 67.9 + / - 4.1 years). Serum IGF-1 level, basal CBF (phase contrast magnetic resonance imaging (MRI)), and NVC responses during the trail making task (with transcranial Doppler sonography) were assessed. We found that circulating IGF-1 levels were significantly decreased with age and associated with decreased basal CBF. Age-related decline in IGF-1 levels predicted the magnitude of age-related decline in NVC responses. In conclusion, our study provides additional evidence in support of the concept that age-related circulating IGF-1 deficiency contributes to neurovascular aging, impairing CBF and functional hyperemia in older adults.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Aging
- cognitive decline
- neurovascular uncoupling
- VCI
- VCID
- vascular cognitive impairment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Toth, Luca
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Czigler, Andras
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Hegedus, Emoke
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Komaromy, Hedvig
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Amrein, Krisztin ...
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Czeiter, Endre
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visa fler...
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Yabluchanskiy, A ...
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Koller, Akos
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Orsi, Gergely
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Perlaki, Gabor
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Schwarcz, Attila
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Büki, Andras, 19 ...
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Ungvari, Zoltan
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Toth, Peter J.
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- MEDICIN OCH HÄLSOVETENSKAP
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