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Relationship of admission blood proteomic biomarkers levels to lesion type and lesion burden in traumatic brain injury : A CENTER-TBI study

Whitehouse, Daniel P. (författare)
University Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Monteiro, Miguel (författare)
Biomedical Image Analysis Group, Department of Computing, Imperial College, London, United Kingdom
Czeiter, Endre (författare)
Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group; Pécs, Hungary
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Vyvere, Thijs Vande (författare)
Research and Development, Icometrix, Leuven, Belgium; Department of Radiology, Antwerp University Hospital and University of Antwerp, Edegem, Belgium
Valerio, Fernanda (författare)
University Division of Anaesthesia, Department of Medicine, University of Cambridge, United Kingdom
Ye, Zheng (författare)
University Division of Anaesthesia, Department of Medicine, University of Cambridge, United Kingdom
Amrein, Krisztina (författare)
Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Kamnitsas, Konstantinos (författare)
Biomedical Image Analysis Group, Department of Computing, Imperial College, London, United Kingdom,Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA; Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center (VAMC), Gainesville Florida, USA,University Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Xu, Haiyan (författare)
Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA
Yang, Zhihui (författare)
Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA
Verheyden, Jan (författare)
Research and Development, Icometrix, Leuven, Belgium
Das, Tilak (författare)
Department of Radiology, Addenbrooke's Hospital, Cambridge, United Kingdom
Kornaropoulos, Evgenios N. (författare)
University Division of Anaesthesia, Department of Medicine, University of Cambridge, United Kingdom
Steyerberg, Ewout (författare)
Center for Medical Decision Making, Department of Public Health, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Biomedical Data Sciences, Leiden University Medical Center, Leiden, Netherlands
Maas, Andrew I. R. (författare)
Department of Neurosurgery, Antwerp University Hospital and University of Antwerp, Edegem, Belgium
Wang, Kevin K.W. (författare)
Program for Neurotrauma, Neuroproteomics and Biomarker Research, Departments of Emergency Medicine, Psychiatry and Neuroscience, University of Florida, McKnight Brain Institute, Gainesville, Florida, USA; Brain Rehabilitation Research Center, Malcom Randall Veterans Affairs Medical Center (VAMC), Gainesville Florida, USA
Büki, Andras, 1966- (författare)
Department of Neurosurgery, Medical School, University of Pécs, Pécs, Hungary; Neurotrauma Research Group, Szentágothai Research Centre, University of Pécs, Pécs, Hungary
Glocker, Ben (författare)
Biomedical Image Analysis Group, Department of Computing, Imperial College, London, United Kingdom
Menon, David K. (författare)
University Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
Newcombe, Virginia F. J. (författare)
University Division of Anaesthesia, Department of Medicine, University of Cambridge, Cambridge, United Kingdom
CENTER-TBI Participants and Investigators, - (bidragsgivare)
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 (creator_code:org_t)
Elsevier, 2022
2022
Engelska.
Ingår i: EBioMedicine. - : Elsevier. - 2352-3964. ; 75
Relaterad länk:
https://doi.org/10.1...
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http://www.thelancet...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • Background: We aimed to understand the relationship between serum biomarker concentration and lesion type and volume found on computed tomography (CT) following all severities of TBI.Methods: Concentrations of six serum biomarkers (GFAP, NFL, NSE, S100B, t-tau and UCH-L1) were measured in samples obtained <24 hours post-injury from 2869 patients with all severities of TBI, enrolled in the CENTER-TBI prospective cohort study (NCT02210221). Imaging phenotypes were defined as intraparenchymal haemorrhage (IPH), oedema, subdural haematoma (SDH), extradural haematoma (EDH), traumatic subarachnoid haemorrhage (tSAH), diffuse axonal injury (DAI), and intraventricular haemorrhage (IVH). Multivariable polynomial regression was performed to examine the association between biomarker levels and both distinct lesion types and lesion volumes. Hierarchical clustering was used to explore imaging phenotypes; and principal component analysis and k-means clustering of acute biomarker concentrations to explore patterns of biomarker clustering.Findings: 2869 patient were included, 68% (n=1946) male with a median age of 49 years (range 2-96). All severities of TBI (mild, moderate and severe) were included for analysis with majority (n=1946, 68%) having a mild injury (GCS 13-15). Patients with severe diffuse injury (Marshall III/IV) showed significantly higher levels of all measured biomarkers, with the exception of NFL, than patients with focal mass lesions (Marshall grades V/VI). Patients with either DAI+IVH or SDH+IPH+tSAH, had significantly higher biomarker concentrations than patients with EDH. Higher biomarker concentrations were associated with greater volume of IPH (GFAP, S100B, t-tau;adj r2 range:0·48-0·49; p<0·05), oedema (GFAP, NFL, NSE, t-tau, UCH-L1;adj r2 range:0·44-0·44; p<0·01), IVH (S100B;adj r2 range:0.48-0.49; p<0.05), Unsupervised k-means biomarker clustering revealed two clusters explaining 83·9% of variance, with phenotyping characteristics related to clinical injury severity.Interpretation: Interpretation: Biomarker concentration within 24 hours of TBI is primarily related to severity of injury and intracranial disease burden, rather than pathoanatomical type of injury.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Neurologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Neurology (hsv//eng)

Nyckelord

Biomarkers
brain injury
traumatic
omputed tomography
neuroimaging

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