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Sökning: WFRF:(Hauss J) > (2020-2024) > Identification and ...

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Nyström, Niklas (författare)
Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden
Mathisen, Charlotte Bache-Wiig (författare)
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
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Kruse, Robert, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
Olbjørn, Christine (författare)
Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway
Andersen, Svend (författare)
Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway
Noble, Alexandra J. (författare)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
Dorn-Rasmussen, Maria (författare)
Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Bazov, Igor, 1973- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Perminow, Gøri (författare)
Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway
Opheim, Randi (författare)
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
Detlie, Trond Espen (författare)
Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
Huppertz-Hauss, Gert (författare)
Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway
Hedin, Charlotte R. H. (författare)
Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden
Carlson, Marie (författare)
Department of Medical Sciences, Uppsala University, Uppsala, Sweden
Öhman, Lena (författare)
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Magnusson, Maria K. (författare)
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Keita, Åsa V. (författare)
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
Söderholm, Johan D. (författare)
Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden
D'Amato, Mauro (författare)
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland
Wewer, Vibeke (författare)
Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Satsangi, Jack (författare)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom
Lindqvist, Carl Mårten, 1979- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Burisch, Johan (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark
Uhlig, Holm H. (författare)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK
Repsilber, Dirk, 1971- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik
Høivik, Marte Lie (författare)
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway
Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
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 (creator_code:org_t)
Springer Nature, 2024
2024
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

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