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Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
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- Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
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- Nyström, Niklas (författare)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
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- Mathisen, Charlotte Bache-Wiig (författare)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Kruse, Robert, 1972- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Clin Res Lab, Örebro, Sweden.
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- Olbjørn, Christine (författare)
- Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Dept Pediat & Adolescent Med, Lorenskog, Norway.
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- Andersen, Svend (författare)
- Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway,Vestfold Hosp Trust, Dept Pediat, Tonsberg, Norway.
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- Noble, Alexandra J. (författare)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.
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- Dorn-Rasmussen, Maria (författare)
- Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.
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- Bazov, Igor, 1973- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
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- Perminow, Gøri (författare)
- Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Pediat Med, Oslo, Norway.
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- Opheim, Randi (författare)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Detlie, Trond Espen (författare)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Dept Gastroenterol, Lorenskog, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Huppertz-Hauss, Gert (författare)
- Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway,Telemark Hosp Trust, Dept Gastroenterol, Skien, Norway.
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- Hedin, Charlotte R. H. (författare)
- Karolinska Institutet
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- Carlson, Marie, 1957- (författare)
- Uppsala universitet,Gastroenterologi/hepatologi
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- Öhman, Lena (författare)
- Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.
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- Magnusson, Maria K. (författare)
- Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.
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- Keita, Åsa (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
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- Söderholm, Johan D (författare)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
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- D'Amato, Mauro (författare)
- IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy,Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.;CIC bioGUNE BRTA, Gastrointestinal Genet Lab, Derio, Spain.;LUM Univ, Dept Med & Surg, Casamassima, Italy.
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- Oresic, Matej, 1967- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Univ Turku, Turku Biosci Ctr, Turku, Finland.;Abo Akad Univ, Turku, Finland.
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- Wewer, Vibeke (författare)
- Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.
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- Satsangi, Jack (författare)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.
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- Lindqvist, Carl Mårten, 1979- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
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- Burisch, Johan (författare)
- Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Med Div, Gastrounit, Hvidovre, Denmark.
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- Uhlig, Holm H. (författare)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.;Univ Oxford, Dept Paediat, Oxford, England.
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- Repsilber, Dirk, 1971- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
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- Hyötyläinen, Tuulia, 1971- (författare)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro Univ, Sch Sci & Technol, Örebro, Sweden.
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- Høivik, Marte Lie (författare)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
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- Halfvarson, Jonas, 1970- (författare)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.
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(creator_code:org_t)
- Springer Nature, 2024
- 2024
- Engelska.
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Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Salihovic, Samir ...
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Nyström, Niklas
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Mathisen, Charlo ...
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Kruse, Robert, 1 ...
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Olbjørn, Christi ...
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Andersen, Svend
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visa fler...
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Noble, Alexandra ...
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Dorn-Rasmussen, ...
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Bazov, Igor, 197 ...
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Perminow, Gøri
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Opheim, Randi
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Detlie, Trond Es ...
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Huppertz-Hauss, ...
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Hedin, Charlotte ...
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Carlson, Marie, ...
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Öhman, Lena
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Magnusson, Maria ...
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Keita, Åsa
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Söderholm, Johan ...
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D'Amato, Mauro
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Oresic, Matej, 1 ...
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Wewer, Vibeke
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Satsangi, Jack
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Lindqvist, Carl ...
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Burisch, Johan
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Uhlig, Holm H.
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Repsilber, Dirk, ...
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Hyötyläinen, Tuu ...
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Høivik, Marte Li ...
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Halfvarson, Jona ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
- Artiklar i publikationen
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Nature Communica ...
- Av lärosätet
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Örebro universitet
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Linköpings universitet
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Uppsala universitet
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Karolinska Institutet