SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Hauss J)
 

Sökning: WFRF:(Hauss J) > Identification and ...

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease

Salihovic, Samira, Associate Senior Lecturer, 1985- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
Nyström, Niklas (författare)
Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
Mathisen, Charlotte Bache-Wiig (författare)
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
visa fler...
Kruse, Robert, 1972- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Clin Res Lab, Örebro, Sweden.
Olbjørn, Christine (författare)
Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Dept Pediat & Adolescent Med, Lorenskog, Norway.
Andersen, Svend (författare)
Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway,Vestfold Hosp Trust, Dept Pediat, Tonsberg, Norway.
Noble, Alexandra J. (författare)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.
Dorn-Rasmussen, Maria (författare)
Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.
Bazov, Igor, 1973- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
Perminow, Gøri (författare)
Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Pediat Med, Oslo, Norway.
Opheim, Randi (författare)
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
Detlie, Trond Espen (författare)
Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Dept Gastroenterol, Lorenskog, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
Huppertz-Hauss, Gert (författare)
Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway,Telemark Hosp Trust, Dept Gastroenterol, Skien, Norway.
Hedin, Charlotte R. H. (författare)
Karolinska Institutet
Carlson, Marie, 1957- (författare)
Uppsala universitet,Gastroenterologi/hepatologi
Öhman, Lena (författare)
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.
Magnusson, Maria K. (författare)
Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.
Keita, Åsa (författare)
Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
Söderholm, Johan D (författare)
Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
D'Amato, Mauro (författare)
IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy,Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.;CIC bioGUNE BRTA, Gastrointestinal Genet Lab, Derio, Spain.;LUM Univ, Dept Med & Surg, Casamassima, Italy.
Oresic, Matej, 1967- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Univ Turku, Turku Biosci Ctr, Turku, Finland.;Abo Akad Univ, Turku, Finland.
Wewer, Vibeke (författare)
Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.
Satsangi, Jack (författare)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.
Lindqvist, Carl Mårten, 1979- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
Burisch, Johan (författare)
Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Med Div, Gastrounit, Hvidovre, Denmark.
Uhlig, Holm H. (författare)
Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.;Univ Oxford, Dept Paediat, Oxford, England.
Repsilber, Dirk, 1971- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
Hyötyläinen, Tuulia, 1971- (författare)
Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro Univ, Sch Sci & Technol, Örebro, Sweden.
Høivik, Marte Lie (författare)
Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
Halfvarson, Jonas, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.
visa färre...
 (creator_code:org_t)
Springer Nature, 2024
2024
Engelska.
Ingår i: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Pediatrik (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Pediatrics (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy