Search: WFRF:(Dorn Rasmussen Maria) >
Identification and ...
Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease
-
- Salihovic, Samira, Associate Senior Lecturer, 1985- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
-
- Nyström, Niklas (author)
- Uppsala universitet,Pediatrisk inflammations- och metabolismforskning samt barnhälsa
-
- Mathisen, Charlotte Bache-Wiig (author)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
show more...
-
- Kruse, Robert, 1972- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Clinical Research Laboratory, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Clin Res Lab, Örebro, Sweden.
-
- Olbjørn, Christine (author)
- Department of Pediatrics and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway,Akershus Univ Hosp, Dept Pediat & Adolescent Med, Lorenskog, Norway.
-
- Andersen, Svend (author)
- Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway,Vestfold Hosp Trust, Dept Pediat, Tonsberg, Norway.
-
- Noble, Alexandra J. (author)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.
-
- Dorn-Rasmussen, Maria (author)
- Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.
-
- Bazov, Igor, 1973- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
-
- Perminow, Gøri (author)
- Department of Pediatric Medicine, Oslo University Hospital, Oslo, Norway,Oslo Univ Hosp, Dept Pediat Med, Oslo, Norway.
-
- Opheim, Randi (author)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
- Detlie, Trond Espen (author)
- Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Dept Gastroenterol, Lorenskog, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
- Huppertz-Hauss, Gert (author)
- Department of Gastroenterology, Telemark Hospital Trust, Skien, Norway,Telemark Hosp Trust, Dept Gastroenterol, Skien, Norway.
-
- Hedin, Charlotte R. H. (author)
- Karolinska Institutet
-
- Carlson, Marie, 1957- (author)
- Uppsala universitet,Gastroenterologi/hepatologi
-
- Öhman, Lena (author)
- Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.
-
- Magnusson, Maria K. (author)
- Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden,Univ Gothenburg, Inst Biomed, Sahlgrenska Acad, Dept Microbiol & Immunol, Gothenburg, Sweden.
-
- Keita, Åsa (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
-
- Söderholm, Johan D (author)
- Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Kirurgiska kliniken US,Linköping Univ, Dept Biomed & Clin Sci, Linköping, Sweden.
-
- D'Amato, Mauro (author)
- IKERBASQUE, Basque Foundation for Science, Bilbao, Spain; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Department of Medicine & Surgery, LUM University, Casamassima, Italy,Basque Fdn Sci, IKERBASQUE, Bilbao, Spain.;CIC bioGUNE BRTA, Gastrointestinal Genet Lab, Derio, Spain.;LUM Univ, Dept Med & Surg, Casamassima, Italy.
-
- Oresic, Matej, 1967- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.;Univ Turku, Turku Biosci Ctr, Turku, Finland.;Abo Akad Univ, Turku, Finland.
-
- Wewer, Vibeke (author)
- Department of Paediatric and Adolescence Medicine, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Dept Paediat & Adolescence Med, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.
-
- Satsangi, Jack (author)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.
-
- Lindqvist, Carl Mårten, 1979- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
-
- Burisch, Johan (author)
- Copenhagen Center for Inflammatory Bowel Disease in Children, Adolescents and Adults, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark; Gastrounit, medical division, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre, Denmark,Copenhagen Univ Hosp Amager & Hvidovre, Copenhagen Ctr Inflammatory Bowel Dis Children Ado, Hvidovre, Denmark.;Copenhagen Univ Hosp Amager & Hvidovre, Med Div, Gastrounit, Hvidovre, Denmark.
-
- Uhlig, Holm H. (author)
- Translational Gastroenterology Unit, Nuffield Department of Experimental Medicine, University of Oxford, Oxford, United Kingdom; Biomedical Research Center, University of Oxford, Oxford, United Kingdom; Department of Paediatrics, University of Oxford, Oxford, UK,Univ Oxford, Nuffield Dept Expt Med, Translat Gastroenterol Unit, Oxford, England.;Univ Oxford, Biomed Res Ctr, Oxford, England.;Univ Oxford, Dept Paediat, Oxford, England.
-
- Repsilber, Dirk, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Örebro Univ, Fac Med & Hlth, Sch Med Sci, Örebro, Sweden.
-
- Hyötyläinen, Tuulia, 1971- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Örebro Univ, Sch Sci & Technol, Örebro, Sweden.
-
- Høivik, Marte Lie (author)
- Department of Gastroenterology, Oslo University Hospital, Oslo, Norway and Faculty of Medicine, University of Oslo, Oslo, Norway,Oslo Univ Hosp, Dept Gastroenterol, Oslo, Norway.;Univ Oslo, Fac Med, Oslo, Norway.
-
- Halfvarson, Jonas, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Örebro Univ, Fac Med & Hlth, Dept Gastroenterol, Örebro, Sweden.
-
show less...
-
(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
-
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://uu.diva-port... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Improved biomarkers are needed for pediatric inflammatory bowel disease. Here we identify a diagnostic lipidomic signature for pediatric inflammatory bowel disease by analyzing blood samples from a discovery cohort of incident treatment-naïve pediatric patients and validating findings in an independent inception cohort. The lipidomic signature comprising of only lactosyl ceramide (d18:1/16:0) and phosphatidylcholine (18:0p/22:6) improves the diagnostic prediction compared with high-sensitivity C-reactive protein. Adding high-sensitivity C-reactive protein to the signature does not improve its performance. In patients providing a stool sample, the diagnostic performance of the lipidomic signature and fecal calprotectin, a marker of gastrointestinal inflammation, does not substantially differ. Upon investigation in a third pediatric cohort, the findings of increased lactosyl ceramide (d18:1/16:0) and decreased phosphatidylcholine (18:0p/22:6) absolute concentrations are confirmed. Translation of the lipidomic signature into a scalable diagnostic blood test for pediatric inflammatory bowel disease has the potential to support clinical decision making.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Salihovic, Samir ...
-
Nyström, Niklas
-
Mathisen, Charlo ...
-
Kruse, Robert, 1 ...
-
Olbjørn, Christi ...
-
Andersen, Svend
-
show more...
-
Noble, Alexandra ...
-
Dorn-Rasmussen, ...
-
Bazov, Igor, 197 ...
-
Perminow, Gøri
-
Opheim, Randi
-
Detlie, Trond Es ...
-
Huppertz-Hauss, ...
-
Hedin, Charlotte ...
-
Carlson, Marie, ...
-
Öhman, Lena
-
Magnusson, Maria ...
-
Keita, Åsa
-
Söderholm, Johan ...
-
D'Amato, Mauro
-
Oresic, Matej, 1 ...
-
Wewer, Vibeke
-
Satsangi, Jack
-
Lindqvist, Carl ...
-
Burisch, Johan
-
Uhlig, Holm H.
-
Repsilber, Dirk, ...
-
Hyötyläinen, Tuu ...
-
Høivik, Marte Li ...
-
Halfvarson, Jona ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Gastroenterology ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Pediatrics
- Articles in the publication
-
Nature Communica ...
- By the university
-
Örebro University
-
Linköping University
-
Uppsala University
-
Karolinska Institutet