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  • Baldimtsi, EvangeliaDepartment of Acute Internal Medicine and Geriatrics in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden (författare)

HbA1c and the risk of developing peripheral neuropathy in childhood-onset type 1 diabetes : A follow-up study over 3 decades

  • Artikel/kapitelEngelska2024

Förlag, utgivningsår, omfång ...

  • John Wiley & Sons,2024
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:oru-114254
  • https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-114254URI
  • https://doi.org/10.1002/dmrr.3825DOI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • Financial support was received from Linköping University, Sweden, ALF grants (Swedish governmental funding of clinical research), and the Medical Research Council of Southeast Sweden.
  • AIMS: We have evaluated long-term weighted mean HbA1c (wHbA1c), HbA1c variability, diabetes duration, and lipid profiles in relation to the development of diabetic peripheral neuropathy (DPN), nephropathy, and retinopathy in childhood-onset type 1 diabetes.MATERIALS AND METHODS: In a longitudinal cohort study, 49 patients (21 women) with childhood-onset type 1 diabetes were investigated with neurophysiological measurements, blood tests, and clinical examinations after a diabetes duration of 7.7 (±3.3) years (baseline) and followed with repeated examinations for 30.6 (±5.2) years. We calculated wHbA1c by integrating the area under all HbA1c values since the diabetes diagnosis. Lipid profiles were analysed in relation to the presence of DPN. Long-term fluctuations of HbA1c variability were computed as the standard deviation of all HbA1c measurements. Data regarding the presence of other diabetes complications were retrieved from medical records.RESULTS: In this follow-up study, 51% (25/49) of the patients fulfilled electrophysiological criteria for DPN. In nerve conduction studies, there was a deterioration in the amplitudes and conduction velocities for the median, peroneal, and sural nerves over time. Patients with DPN had a longer duration of diabetes, higher wHbA1c, and increased HbA1c variability. The lowest wHbA1c value associated with the development of DPN was 62 mmol/mol (7.8%). The presence of albuminuria and retinopathy was positively correlated with the presence of neuropathy.CONCLUSIONS: More than half of the patients had developed DPN after 30 years. None of the patients who developed DPN had a wHbA1c of less than 62 mmol/mol (7.8%).

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Amezcua, SalvadorDepartment of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden (författare)
  • Ulander, MartinDepartment of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden (författare)
  • Hyllienmark, LarsClinical Neurophysiology, Karolinska University Hospital, and Karolinska Institute, Stockholm, Sweden (författare)
  • Olausson, HåkanDepartment of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden (författare)
  • Ludvigsson, JohnnyDepartment of Biomedical and Clinical Sciences, Crown Princess Victoria's Children Hospital and Division of Pediatrics, Linköping University, Linköping, Sweden (författare)
  • Wahlberg, Jeanette,1969-Örebro universitet,Institutionen för medicinska vetenskaper,Department of Acute Internal Medicine and Geriatrics in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, Sweden(Swepub:oru)jewg (författare)
  • Department of Acute Internal Medicine and Geriatrics in Linköping, Department of Health, Medicine and Caring Sciences, Linköping University, Linköping, SwedenDepartment of Biomedical and Clinical Medicine, Linköping University, Centre for Social and Affective Neuroscience, Linköping, Sweden (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Diabetes/Metabolism Research Reviews: John Wiley & Sons40:51520-75521520-7560

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